1,2,3,4-tetrahydrobenzo[b]azocine | 34786-00-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 1,2,3,4-tetrahydrobenzo[b]azocine
• 英文别名: 1,2,3,4-tetrahydro-1-benzazocine；tetrahydro benzoazocine；tetrahydrobenzazocine；Tetrahydrobenzoazocine；(5Z)-1,2,3,4-tetrahydro-1-benzazocine
• CAS: 34786-00-0
• 化学式: C₁₁H₁₃N
• 分子量: 159.231
• InChiKey: ZCRPYCNRFPQFBJ-KXFIGUGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
  申请人：The Johns Hopkins University

  公开号：EP2672822A1

  公开（公告）日：2013-12-18
• [EN] METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION<br/>[FR] PROCÉDÉS ET COMPOSITION POUR AMÉLIORER LA FONCTION COGNITIVE
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2012109491A1

  公开（公告）日：2012-08-16

  This invention relates to methods and compositions for treating central nervous system (CNS) disorders with cognitive impairment. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2A (SV2A), alone or in combination with valproate, in treating central nervous system (CNS) disorders with cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI (aMCl ), Age- Associated Memory Impairment (AAMI), Age Related Cognitive Decline (ARCD), dementia, Alzheimer's Disease(AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, amyotrphic lateral sclerosis and cancer-therapy-related cognitive impairment.