methyl (2R)-3-(4-methoxyphenyl)-2-methylpropanoate | 1239477-89-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl (2R)-3-(4-methoxyphenyl)-2-methylpropanoate
• CAS: 1239477-89-4
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: WHARKKWCIIVVCY-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl (2R)-3-(4-methoxyphenyl)-2-methylpropanoate 、 氨基磺酸-2,2,2-三氯乙酯 在 bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} 、 碘苯二乙酸 作用下， 以 苯 为溶剂， 生成 (2S*,3S*)-methyl 3-(4-methoxyphenyl)-2-methyl-3-(((2,2,2-trichloroethoxy)sulfonyl)amino)propanoate 、
  参考文献：
  名称：

  Acyclic Stereocontrol in the Catalytic C−H Amination of Benzylic Methylene Groups

  摘要：

  Diastereotopos-differentiation is the key feature of the catalytic C-H amination at the benzylic position of substrate 1. Essentially independent of the functional group X (X = COOMe, PO(OEt)(2), SO(2)Ph, NO(2), CN, OAc), the depicted products 2 are formed with good (dr = 80/20) to excellent (dr > 95/5) diastereoselectivity. The reaction proceeds without racemization and possesses potential for the C-H amination of open-chain substrates.

  DOI：

  10.1021/ol101517v

文献信息

• Acyclic Stereocontrol in the Catalytic C−H Amination of Benzylic Methylene Groups
  作者：Anike Nörder、Pavel Herrmann、Eberhard Herdtweck、Thorsten Bach

  DOI：10.1021/ol101517v

  日期：2010.8.20

  Diastereotopos-differentiation is the key feature of the catalytic C-H amination at the benzylic position of substrate 1. Essentially independent of the functional group X (X = COOMe, PO(OEt)(2), SO(2)Ph, NO(2), CN, OAc), the depicted products 2 are formed with good (dr = 80/20) to excellent (dr > 95/5) diastereoselectivity. The reaction proceeds without racemization and possesses potential for the C-H amination of open-chain substrates.