1-(4-Hydrazinylbenzene-1-sulfonyl)-2,5-dimethyl-1H-pyrrole | 518974-88-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-Hydrazinylbenzene-1-sulfonyl)-2,5-dimethyl-1H-pyrrole
• 英文别名: [4-(2,5-dimethylpyrrol-1-yl)sulfonylphenyl]hydrazine
• CAS: 518974-88-4
• 化学式: C₁₂H₁₅N₃O₂S
• 分子量: 265.33
• InChiKey: HTFUNXUXXJXNPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  85.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Substituted indazole compounds for the treatment of inflammation
  申请人：——

  公开号：US20030109550A1

  公开（公告）日：2003-06-12

  The present invention relates to substituted indazole derivatives, compositions comprising such, intermediates, methods of making substituted indazolel derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

  本发明涉及取代吲唑衍生物、包含此类衍生物的组合物、中间体、制备取代吲唑衍生物的方法，以及治疗癌症、炎症和炎症相关疾病（如关节炎）的方法。
• SUBSTITUTED INDAZOLE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION
  申请人：Pharmacia Corporation

  公开号：EP1427707A1

  公开（公告）日：2004-06-16
• TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION
  申请人：Pharmacia Corporation

  公开号：EP1476431A1

  公开（公告）日：2004-11-17
• [EN] SUBSTITUTED INDAZOLE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION<br/>[FR] COMPOSES D'INDAZOLE SUBSTITUES DESTINES AU TRAITEMENT DE L'INFLAMMATION
  申请人：PHARMACIA CORP

  公开号：WO2003035625A1

  公开（公告）日：2003-05-01

  The present invention relates to substituted indazole derivatives, compositions comprising such, intermediates, methods of making substituted indazolel derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.
• [EN] TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION<br/>[FR] DERIVES DE PYRAZOLE TRICYCLIQUES UTILISES DANS LE TRAITEMENT DES INFLAMMATIONS
  申请人：PHARMACIA CORP

  公开号：WO2003070706A1

  公开（公告）日：2003-08-28

  The present invention relates to substituted tricyclic pyrazole derivatives, compositions comprising such, intermediates, methods of making tricyclic pyrazole derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.