(R)-N-(2-(1H-indol-3-yl)ethyl)-2-(5-fluoropyridin-3-yl)-9-(tetrahydrofuran-3-yl)-9H-purin-6-amine | 1227634-48-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (R)-N-(2-(1H-indol-3-yl)ethyl)-2-(5-fluoropyridin-3-yl)-9-(tetrahydrofuran-3-yl)-9H-purin-6-amine
• 英文别名: 2-(5-fluoropyridin-3-yl)-N-[2-(1H-indol-3-yl)ethyl]-9-[(3R)-oxolan-3-yl]purin-6-amine
• CAS: 1227634-48-1
• 化学式: C₂₄H₂₂FN₇O
• 分子量: 443.483
• InChiKey: PWTFJRRVHPTEFT-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  93.5
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Enhancement of Natural Killer (NK) Cell Proliferation and Activity
  申请人：Gamida Cell Ltd.

  公开号：US20140023626A1

  公开（公告）日：2014-01-23

  Methods of ex-vivo culture of natural killer (NK) cells are provided and, more particularly, methods for enhancing propagation and/or functionality of NK cells by treating the cells with an aryl hydrocarbon antagonist in combination with cytokines driving NK cell proliferation. Also envisioned are compositions comprising cultured NK cells and therapeutic uses thereof.

  提供了自体培养自然杀伤细胞（NK细胞）的方法，更具体地，通过将细胞与芳香族碳氢化合物拮抗剂和促进NK细胞增殖的细胞因子联合处理，提高NK细胞的繁殖和/或功能。此外，还设想了包含培养的NK细胞的组合物及其治疗用途。
• Methods of Culturing and Expanding Mesenchymal Stem Cells and Isolated Cell Populations Generated Thereby
  申请人：Gamida Cell Ltd.

  公开号：US20140023623A1

  公开（公告）日：2014-01-23

  A method of culturing mesenchymal stem cells (MSCs) is provided. The method comprising culturing a population of the MSCs in a medium comprising an aryl hydrocarbon receptor antagonist, thereby culturing MSCs.

  提供了一种培养间充质干细胞（MSCs）的方法。该方法包括在含有芳香族羟基化合物受体拮抗剂的培养基中培养MSCs的群体，从而培养MSCs。
• COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS
  申请人：Boitano Anthony E.

  公开号：US20100183564A1

  公开（公告）日：2010-07-22

  The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.

  本发明涉及用于扩增CD34+细胞数量的化合物和组合物。该发明进一步涉及包含扩增造血干细胞（HSCs）的细胞群体及其在自体或异体移植中的使用，用于治疗遗传性免疫缺陷和自身免疫性疾病以及不同的造血障碍，以重建造血细胞系和免疫系统防御。
• EXPANDED HEMATOPOIETIC STEM CELLS FROM CORD BLOOD AND THEIR THERAPEUTIC USE
  申请人：Novartis AG

  公开号：EP3524604A1

  公开（公告）日：2019-08-14

  The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.

  本发明涉及用于扩大移植用CD34+细胞数量的化合物和组合物。本发明进一步涉及由扩增的造血干细胞（HSCs）组成的细胞群及其在自体或异体移植中的用途，用于治疗遗传性免疫缺陷和自身免疫性疾病以及各种造血疾病患者，以重建造血细胞系和免疫系统防御。
• COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS
  申请人：Fred Hutchinson Cancer Research Center

  公开号：EP2788476B1

  公开（公告）日：2019-05-22