2-benzyl-4-bromo-5-phenethoxypyridazin-3(2H)-one | 565156-98-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-benzyl-4-bromo-5-phenethoxypyridazin-3(2H)-one
• 英文别名: 2-benzyl-4-bromo-5-(2-phenylethoxy)pyridazin-3-one
• CAS: 565156-98-1
• 化学式: C₁₉H₁₇BrN₂O₂
• 分子量: 385.3
• InChiKey: LITJOHNZWPWNPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Substituted pyridazinones
  申请人：Hepperle Michael

  公开号：US20050020594A1

  公开（公告）日：2005-01-27

  Disclosed are substituted pyridazinones that are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical composition containing the pyridazinone compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

  公开了用于治疗由不受调控的p38 MAP激酶和/或TNF活性引起或加重的疾病和病况的替代吡啶并酮。还公开了含有吡啶并酮化合物的药物组合物、制备该化合物的方法以及使用该化合物进行治疗的方法。
• SUBSTITUTED PYRIDAZINONES AS INHIBITORS OF P38
  申请人：Pharmacia Corporation

  公开号：EP1470112A1

  公开（公告）日：2004-10-27
• JP2005519895A
  申请人：——

  公开号：JP2005519895A

  公开（公告）日：2005-07-07
• [EN] SUBSTITUTED PYRIDAZINONES AS INHIBITORS OF P38<br/>[FR] PYRIDAZINONES SUBSTITUEES INHIBANT LA MAP KINASE P38
  申请人：PHARMACIA CORP

  公开号：WO2003059891A1

  公开（公告）日：2003-07-24

  (Formula I); Disclosed are substituted pyridazinones that are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical composition containing the pyridazinone compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.