2-(1-phenyl-ethyl)-4,5-dihydro-1H-imidazole | 54715-33-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1-phenyl-ethyl)-4,5-dihydro-1H-imidazole
• 英文别名: 2-(1-phenylethyl)-4,5-dihydro-1H-imidazole
• CAS: 54715-33-2
• 化学式: C₁₁H₁₄N₂
• 分子量: 174.246
• InChiKey: GYZWLJYCSUFOPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 次氯酸叔丁酯 作用下， 以 叔丁醇 为溶剂， 反应 10.0h， 生成 2-(1-phenyl-ethyl)-4,5-dihydro-1H-imidazole
  参考文献：
  名称：

  用次氯酸叔丁酯从醛轻松制备 2-咪唑啉

  摘要：

  在次氯酸叔丁酯存在下，由醛和乙二胺高效、高产地制备 2-咪唑啉。通过该方法，可以直接由相应的二醛高收率地制备出作为手性配体的1,3-双(咪唑啉-2-基)苯和2,6-双(咪唑啉-2-基)吡啶。

  DOI：

  10.1055/s-2007-983726

文献信息

• Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives
  申请人：Galley Guido

  公开号：US20070197621A1

  公开（公告）日：2007-08-23

  The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, R 1 , R 2 , A and n are as defined in the specification and to their pharmaceutically active salts. The invention also relates to novel compounds of formula I, pharmaceutical compositions containing them, and methods for their preparation.

  本发明涉及一种治疗抑郁症、焦虑症、双相情感障碍、注意力缺陷多动障碍、压力相关障碍、精神分裂症等精神障碍、帕金森病等神经系统疾病、阿尔茨海默病等神经退行性疾病、癫痫、偏头痛、高血压、物质滥用、进食障碍、糖尿病、糖尿病并发症、肥胖症、血脂异常、能量消耗和吸收障碍、体温稳态障碍、睡眠和昼夜节律障碍以及心血管疾病的方法，包括向个体施用化合物I的治疗有效量，其中R、R1、R2、A和n如规范中所定义，以及其药用活性盐。该发明还涉及化合物I的新颖化合物、含有它们的药物组合物以及它们的制备方法。
• CROSSLINKABLE NITRILE RUBBER COMPOSITION AND CROSSLINKED RUBBER MATERIAL
  申请人：Zeon Corporation

  公开号：EP3239231A1

  公开（公告）日：2017-11-01

  A cross-linkable nitrile rubber composition contains a carboxyl group-containing highly saturated nitrile rubber (A), a resin (B), and a polyamine cross-linking agent (C). The content of the carboxyl group-containing highly saturated nitrile rubber (A) is 30 parts by weight or more with respect to 100 parts by weight of the total amount of the carboxyl group-containing highly saturated nitrile rubber (A) and the resin (B). The cross-linkable nitrile rubber composition is obtained by performing kneading at a temperature equal to or higher than the melting point of the resin (B).

  一种可交联丁腈橡胶组合物含有含羧基的高饱和丁腈橡胶（A）、树脂（B）和多胺交联剂（C）。相对于含羧基的高饱和丁腈橡胶（A）和树脂（B）总量的 100 重量份，含羧基的高饱和丁腈橡胶（A）的含量为 30 重量份或以上。可交联丁腈橡胶组合物是通过在等于或高于树脂（B）熔点的温度下进行捏合获得的。
• Cross-linkable nitrile rubber composition and cross-linked rubber product, and method for manufacturing cross-linkable nitrile rubber composition
  申请人：ZEON CORPORATION

  公开号：US10266681B2

  公开（公告）日：2019-04-23

  A cross-linkable nitrile rubber composition contains a carboxyl group-containing highly saturated nitrile rubber, a resin, and a polyamine cross-linking agent. The content of the carboxyl group-containing highly saturated nitrile rubber is 30 parts by weight or more with respect to 100 parts by weight of the total amount of the carboxyl group-containing highly saturated nitrile rubber and the resin. The cross-linkable nitrile rubber composition is obtained by performing kneading at a temperature equal to or higher than the melting point of the resin.

  一种可交联丁腈橡胶组合物含有含羧基的高饱和丁腈橡胶、树脂和多胺交联剂。相对于含羧基的高饱和度丁腈橡胶和树脂总量的 100 重量份，含羧基的高饱和度丁腈橡胶的含量为 30 重量份或以上。可交联丁腈橡胶组合物是在等于或高于树脂熔点的温度下进行捏合得到的。
• EP1981497A2
  申请人：——

  公开号：EP1981497A2

  公开（公告）日：2008-10-22
• METHOD FOR MANUFACTURING A CROSS-LINKABLE NITRILE RUBBER COMPOSITION AND CROSS-LINKED RUBBER PRODUCT
  申请人：Zeon Corporation

  公开号：EP3239231B1

  公开（公告）日：2020-09-09