4-azidophenyl butyric acid 4-nitrophenyl ester | 253325-35-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 4-azidophenyl butyric acid 4-nitrophenyl ester
• CAS: 253325-35-8
• 化学式: C₁₆H₁₄N₄O₄
• 分子量: 326.312
• InChiKey: RRKYDXBBBMFJBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.46
• 重原子数：
  24.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  118.2
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  4-azidophenyl butyric acid 4-nitrophenyl ester 、 N-[[(1R,2R,3R,4S)-3-[(Z)-7-[2-[5-[(3aR,4R,6aS)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoyl]hydrazinyl]-7-oxohept-2-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]methyl]-2-aminoacetamide 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以88%的产率得到biotinylhydrazido[1S-[1α,2α(Z),3α,4α]]-7-[3-[[[[[(4-azidophenyl)propylcarbonyl]amino]acetyl]amino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoate
  参考文献：
  名称：

  Synthesis and biological characterization of AQPazide, a novel biotinylated photoaffinity probe for the study of the human platelet throm☐ane A2 receptor

  摘要：

  SQBAzide, a biotinylated, azido derivative of the TXA(2) receptor antagonist, SQ31,491, was synthesized and characterized. The compound specifically inhibited human platelet aggregation mediated by TXA(2) receptor activation and irreversibly labeled platelet TXA(2) receptors upon exposure to ultraviolet light. This probe should prove to be of significant value for the study of the receptor-ligand binding domain. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00511-9
• 作为产物：
  描述：

  4-(4-氨基苯基)丁酸 在 硫酸 、 N,N'-二环己基碳二亚胺 、 sodium nitrite 作用下， 以 二氯甲烷 为溶剂， 反应 2.42h， 生成 4-azidophenyl butyric acid 4-nitrophenyl ester
  参考文献：
  名称：

  Synthesis and biological characterization of AQPazide, a novel biotinylated photoaffinity probe for the study of the human platelet throm☐ane A2 receptor

  摘要：

  SQBAzide, a biotinylated, azido derivative of the TXA(2) receptor antagonist, SQ31,491, was synthesized and characterized. The compound specifically inhibited human platelet aggregation mediated by TXA(2) receptor activation and irreversibly labeled platelet TXA(2) receptors upon exposure to ultraviolet light. This probe should prove to be of significant value for the study of the receptor-ligand binding domain. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00511-9