1-Pentyldibenzothiophen | 147792-11-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 1-Pentyldibenzothiophen
• 英文别名: 1-Pentyldibenzothiophene
• CAS: 147792-11-8
• 化学式: C₁₇H₁₈S
• 分子量: 254.396
• InChiKey: SLTUMZHMJVKKMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Pentyldibenzothiophen 在 双氧水 、 溶剂黄146 作用下， 反应 0.17h， 以79%的产率得到1-Pentyldibenzothiophen-5,5-dioxid
  参考文献：
  名称：

  Boberg, Friedrich; Bruns, Wolfgang; Musshoff, Dagmar, Phosphorus, Sulfur and Silicon and the Related Elements, 1992, vol. 72, # 1-4, p. 13 - 32

  摘要：

  DOI：
• 作为产物：
  描述：

  1-Valeryldibenzothiophen 在 氢氧化钾 、 一水合肼 作用下， 生成 1-Pentyldibenzothiophen
  参考文献：
  名称：

  Boberg, Friedrich; Bruns, Wolfgang; Musshoff, Dagmar, Phosphorus, Sulfur and Silicon and the Related Elements, 1992, vol. 72, # 1-4, p. 13 - 32

  摘要：

  DOI：

文献信息

• Heteroaromatic pentacyclic compound and medicinal use thereof
  申请人：Ikemoto Tomoyuki

  公开号：US20060122181A1

  公开（公告）日：2006-06-08

  A 5-membered heteroaromatic ring compound represented by the formula [I] wherein V is CH or N; W is S or O; R 1 and R 2 are each H etc.; X is —N(R 4 )—, —O—, —S—, —SO 2 —N(R 5 )—, —CO—N(R 7 )— etc.; L is wherein R 20 , R 21 , R 22 and R 25 are each H etc.; E is aryl or heteroaromatic ring group; R is —COOH etc.; B is aryl etc.; R 3 is H etc.; Y is —C(R 13 )(R 14 )—N(R 12 )—C(R 13 )(R 14 )—O—, —N(R 11 )—, —O— etc.; A is alkylene; and Z is aryl etc., a prodrug thereof and a pharmaceutically acceptable salt thereof. The compound [I] has a superior protein tyrosine phosphatase 1B inhibitory activity and is useful as a therapeutic agent for diabetes, diabetic complications, hyperlipidemia, obesity and the like.

  一种由公式[I]表示的五元杂环芳香环化合物，其中V为CH或N；W为S或O；R1和R2分别为H等；X为—N(R4)—，—O—，—S—，—SO2—N(R5)—，—CO—N(R7)—等；L为其中R20，R21，R22和R25分别为H等的基团；E为芳基或杂环芳香基团；R为—COOH等；B为芳基等；R3为H等；Y为—C(R13)(R14)—N(R12)—C(R13)(R14)—O—，—N(R11)—，—O—等；A为烷基；Z为芳基等，其前药和药学上可接受的盐。该化合物[I]具有优越的蛋白酪氨酸磷酸酶1B抑制活性，并可用作治疗糖尿病、糖尿病并发症、高脂血症、肥胖症等的治疗剂。
• Azole compound and medicinal use thereof
  申请人：Inaba Takashi

  公开号：US20050065196A1

  公开（公告）日：2005-03-24

  The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is —COOR 7 , —X 1 -A 1 -COOR 7 (R 7 is H, alkyl) or tetrazolyl; R 1 , R 2 , R 3 and R 4 are H and the like; A is —(CH 2 ) m —X— (X is —N(R 8 )—, —C(R 9 )(R 10 )—, —CO— or —CO—N(R 8 )—); B is aryl or aromatic heterocyclic group; R 5 is H and the like; R 6 is —(Y) s1 -(A 2 ) s -Z (Y is —O—, —S(O) t —, —N(R 13 )—, —N(R 14 )—CO—, —N(R 14 )—SO 2 —, —SO 2 —N(R 14 )— and the like, A 2 is alkylene, and Z is cycloalkyl, aryl, aromatic heterocyclic group, indanyl, piperazinyl, a prodrug thereof or a pharmaceutically acceptable salt thereof. The compound [I] of the present invention has a protein tyrosine phosphatase 1B inhibitory activity, and is useful as a therapeutic agent for diabetes, a therapeutic drug for diabetic complications or a therapeutic drug for hyperlipidemia.

  本发明涉及一种由式[I]表示的唑类化合物，其中W为S或O；R为—COOR7，—X1-A1-COOR7（R7为H，烷基）或四唑基；R1、R2、R3和R4为H等；A为—（CH2）m—X—（X为—N（R8）—、—C（R9）（R10）—、—CO—或—CO—N（R8）—）；B为芳基或芳香杂环基；R5为H等；R6为—（Y）s1-（A2）s-Z（Y为—O—、—S（O）t—、—N（R13）—、—N（R14）—CO—、—N（R14）—SO2—、—SO2—N（R14）—等，A2为烷基，Z为环烷基，芳基，芳香杂环基，茚基，哌嗪基，其前体药物或其药学上可接受的盐。本发明的化合物[I]具有蛋白酪氨酸磷酸酶1B抑制活性，并且可用作糖尿病治疗剂、糖尿病并发症治疗药物或高脂血症治疗药物。
• Organic Electroluminescent Device
  申请人：MERCK PATENT GMBH

  公开号：US20160226001A1

  公开（公告）日：2016-08-04

  The invention relates to an organic electroluminescent device (OLED) containing an emitting layer which contains a compound having a small difference between the S 1 and the T 1 energy levels and to another compound of formula (I) or (II).

  本发明涉及一种有机电致发光器件（OLED），其包含一个发光层，该发光层含有一个具有S1和T1能级之间差异小的化合物，以及公式（I）或（II）的另一个化合物。
• AZOLE COMPOUND AND MEDICINAL USE THEREOF
  申请人：Japan Tobacco Inc.

  公开号：EP1452530A1

  公开（公告）日：2004-09-01

  The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is -COOR7, -X1-A1-COOR7 (R7 is H, alkyl) or tetrazolyl; R1, R2, R3 and R4 are H and the like; A is -(CH2)m-X- (X is -N(R8)-, -C(R9)(R10)-, -CO- or -CO-N(R8)-); B is aryl or aromatic heterocyclic group; R5 is H and the like; R6 is -(Y)s1-(A2)s-Z (Y is -O-, -S(O)t-, -N(R13)-, -N(R14)-CO-, -N(R14)-SO2-, -SO2-N(R14)- and the like, A2 is alkylene, and Z is cycloalkyl, aryl, aromatic heterocyclic group, indanyl, piperazinyl, a prodrug thereof or a pharmaceutically acceptable salt thereof. The compound [I] of the present invention has a protein tyrosine phosphatase 1B inhibitory activity, and is useful as a therapeutic agent for diabetes, a therapeutic drug for diabetic complications or a therapeutic drug for hyperlipidemia.

  本发明涉及一种由式[I]表示的唑化合物 其中W是S或O；R是-COOR7、-X1-A1-COOR7（R7是H、烷基）或四唑基；R1、R2、R3和R4是H等；A是-(CH2)m-X-（X是-N(R8)-、-C(R9)(R10)-、-CO-或-CO-N(R8)-）；B是芳基或芳香杂环基团；R5是H等；R6是-(Y)s1-(A2)s-Z（Y是-O-、-S(O)t-、-N(R13)-、-N(R14)-CO-、-N(R14)-SO2-、-SO2-N(R14)-等，A2是亚烷基，Z是环烷基、芳基、芳香杂环基、茚基、哌嗪基、其原药或其药学上可接受的盐。本发明的化合物[I]具有蛋白酪氨酸磷酸酶 1B 抑制活性，可作为糖尿病治疗剂、糖尿病并发症治疗药物或高脂血症治疗药物。
• HETEROAROMATIC PENTACYCLIC COMPOUND AND MEDICINAL USE THEREOF
  申请人：Japan Tobacco Inc.

  公开号：EP1553091A1

  公开（公告）日：2005-07-13

  A 5-membered heteroaromatic ring compound represented by the formula [I] wherein V is CH or N; W is S or O; R1 and R2 are each H etc.; X is -N(R4)-, -O-, -S-, -SO2-N(R5)-, -CO-N(R7)- etc.; L is wherein R20, R21, R22 and R25 are each H etc.; E is aryl or heteroaromatic ring group; R is -COOH etc.; B is aryl etc.; R3 is H etc.; Y is -C(R13)(R14)-N(R12)-, -C(R13)(R14)-O-, -N(R11)-, -O- etc.; A is alkylene; and Z is aryl etc., a prodrug thereof and a pharmaceutically acceptable salt thereof. The compound [I] has a superior protein tyrosine phosphatase 1B inhibitory activity and is useful as a therapeutic agent for diabetes, diabetic complications, hyperlipidemia, obesity and the like.

  由式[I]代表的 5 元杂芳环化合物 其中 V 是 CH 或 N；W 是 S 或 O；R1 和 R2 各自是 H 等；X 是 -N(R4)-、-O-、-S-、-SO2-N(R5)-、-CO-N(R7)- 等；L 是 其中 R20、R21、R22 和 R25 各为 H 等；E 为芳基或杂芳环基团；R 为-COOH 等；B 为芳基等；R3 为 H 等；Y 为-C(R13)(R14)-N(R12)-、-C(R13)(R14)-O-、-N(R11)-、-O- 等；A 为亚烷基；Z 为芳基等、其原药及其药学上可接受的盐。 化合物[I]具有优异的蛋白酪氨酸磷酸酶 1B 抑制活性，可作为糖尿病、糖尿病并发症、高脂血症、肥胖症等的治疗剂。