N8-[2-(3-chlorophenyl)ethyl][1,2,4]triazolo[4,3-a]pyrazine-3,8-diamine | 1313186-58-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N8-[2-(3-chlorophenyl)ethyl][1,2,4]triazolo[4,3-a]pyrazine-3,8-diamine
• 英文别名: 8-N-[2-(3-chlorophenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyrazine-3,8-diamine
• CAS: 1313186-58-1
• 化学式: C₁₃H₁₃ClN₆
• 分子量: 288.739
• InChiKey: VVAUYWDTJJTMKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  81.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Substituted Triazolo-Pyrazine Compounds
  申请人：Westlund Neil

  公开号：US20110160215A1

  公开（公告）日：2011-06-30

  The present invention relates to substituted triazolo-pyrazine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted triazolo-pyrazine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及替代三唑吡嗪化合物及其合成方法。本发明还涉及含有替代三唑吡嗪化合物的药物组合物，以及通过向需要的受试者投与这些化合物和药物组合物来治疗细胞增殖性疾病，如癌症的方法。
• US8329705B2
  申请人：——

  公开号：US8329705B2

  公开（公告）日：2012-12-11
• [EN] SUBSTITUTED TRIAZOLO-PYRAZINE COMPOUNDS<br/>[FR] COMPOSÉS TRIAZOLO-PYRAZINE SUBSTITUÉS
  申请人：ARQULE INC

  公开号：WO2011082267A2

  公开（公告）日：2011-07-07

  The present invention relates to substituted triazolo-pyrazine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted triazolo-pyrazine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.