Tetrahydro-4,4-dimethyl-2,3-furandiol | 103203-99-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢呋喃
• 英文名称: Tetrahydro-4,4-dimethyl-2,3-furandiol
• 英文别名: 4,4-dimethyloxolane-2,3-diol
• CAS: 103203-99-2
• 化学式: C₆H₁₂O₃
• 分子量: 132.16
• InChiKey: DIKRRYQLMNTQDF-UHFFFAOYSA-N

物化性质

• 沸点：
  214.3±40.0 °C(Predicted)
• 密度：
  1.178±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Novel carbonyl reductase, gene thereof and use of the same
  申请人：Kizaki Noriyuki

  公开号：US20060046289A1

  公开（公告）日：2006-03-02

  The present invention provides a novel polypeptide forming (R)-2-chloro-1-(3′-chlorophenyl)ethanol, a polynucleotide coding for said polypeptide, and use of the same. The present invention relates to a polypeptide having the following physical and chemical properties (1) to (4): (1) activity: acting on 2-chloro-1-(3′-chlorophenyl)ethanone with NADPH or NADH as a coenzyme, to form (R)-2-chloro-1-(31-chlorophenyl)ethanol; (2) optimum pH for activity: 5.0 to 6.0; (3) optimum temperature for activity: 40° C. to 50° C.; (4) molecular weight: about 40,000 as determined by gel filtration analysis, about 30,000 as determined by SDS polyacrylamide gel electrophoresis analysis. The present invention also relates to a polypeptide comprising the amino acid sequence shown under SEQ ID NO:1 in the sequence listing, a polynucleotide coding for said polypeptide, and a transformant producing said polypeptide at high levels.

  本发明提供了一种新型多肽，可形成(R)-2-氯-1-(3'-氯苯基)乙醇，编码该多肽的多核苷酸，以及其用途。本发明涉及具有以下物理和化学性质(1)至(4)的多肽：(1)活性：利用NADPH或NADH作为辅酶，对2-氯-1-(3'-氯苯基)乙酮进行作用，形成(R)-2-氯-1-(3'-氯苯基)乙醇；(2)最适pH值：5.0至6.0；(3)最适活性温度：40℃至50℃；(4)分子量：通过凝胶过滤分析确定约为40,000，通过SDS聚丙烯酰胺凝胶电泳分析确定约为30,000。本发明还涉及包含序列列表中SEQ ID NO:1所示氨基酸序列的多肽，编码该多肽的多核苷酸，以及产生高水平该多肽的转化菌。
• US7332312B2
  申请人：——

  公开号：US7332312B2

  公开（公告）日：2008-02-19