2,4-diethyl-1,3,5,8-tetramethyl-6,7-bis(3-methylsulphonyl-propyl)porphyrin | 10250-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: 2,4-diethyl-1,3,5,8-tetramethyl-6,7-bis(3-methylsulphonyl-propyl)porphyrin
• CAS: 10250-34-7
• 化学式: C₃₆H₄₆N₄O₆S₂
• 分子量: 694.916
• InChiKey: KZVGSBMZFGGCRZ-LHPWBCDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.43
• 重原子数：
  48.0
• 可旋转键数：
  12.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  144.1
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  2,4-diethyl-1,3,5,8-tetramethyl-6,7-bis(3-methylsulphonyl-propyl)porphyrin 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 6,7-dipropylmesochlorin (ring-B reduced)
  参考文献：
  名称：

  Burns, Dennis H.; Lai, Jan-Ji; Smith, Kevin M., Journal of the Chemical Society. Perkin transactions I, 1988, p. 3119 - 3132

  摘要：

  DOI：
• 作为产物：
  描述：

  mesoporphyrin IX DME 在 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 9.0h， 生成 2,4-diethyl-1,3,5,8-tetramethyl-6,7-bis(3-methylsulphonyl-propyl)porphyrin
  参考文献：
  名称：

  Burns, Dennis H.; Lai, Jan-Ji; Smith, Kevin M., Journal of the Chemical Society. Perkin transactions I, 1988, p. 3119 - 3132

  摘要：

  DOI：

文献信息

• [EN] YAP1 INHIBITORS AND METHODS<br/>[FR] INHIBITEURS DE LA YAP1 ET MÉTHODES ASSOCIÉES
  申请人：JACKSON LAB

  公开号：WO2017197104A1

  公开（公告）日：2017-11-16

  YAP1 inhibitors and methods of treating a subject with a cancer that include administering a YAP1 inhibitor are disclosed. Also disclosed are methods for determining responsiveness to a YAP1 inhibitor in a subject, methods for diagnosing a tumor in a subject including determining the level of YAP1 expression, compositions that include YAP1 inhibitors, and methods of using those compositions.

  揭示了YAP1抑制剂和治疗癌症的方法，包括给患有癌症的受试者施用YAP1抑制剂。还公开了一种确定受试者对YAP1抑制剂响应性的方法，包括确定受试者肿瘤的诊断方法，其中包括确定YAP1表达水平，含有YAP1抑制剂的组合物，以及使用这些组合物的方法。
• YAP1 inhibitors and methods
  申请人：The Jackson Laboratory

  公开号：US11331304B2

  公开（公告）日：2022-05-17

  YAP1 inhibitors and methods of treating a subject with a cancer that include administering a YAP1 inhibitor are disclosed. Also disclosed are methods for determining responsiveness to a YAP1 inhibitor in a subject, methods for diagnosing a tumor in a subject including determining the level of YAP1 expression, compositions that include YAP1 inhibitors, and methods of using those compositions.

  本研究公开了YAP1抑制剂和治疗癌症患者的方法，其中包括施用YAP1抑制剂。还公开了确定受试者对 YAP1 抑制剂的反应性的方法、诊断受试者肿瘤的方法（包括确定 YAP1 表达水平）、包括 YAP1 抑制剂的组合物以及使用这些组合物的方法。
• YAP1 INHIBITORS AND METHODS
  申请人：The Jackson Laboratory

  公开号：US20190298693A1

  公开（公告）日：2019-10-03

  YAP1 inhibitors and methods of treating a subject with a cancer that include administering a YAP1 inhibitor are disclosed. Also disclosed are methods for determining responsiveness to a YAP1 inhibitor in a subject, methods for diagnosing a tumor in a subject including determining the level of YAP1 expression, compositions that include YAP1 inhibitors, and methods of using those compositions.