4-{[(1S)-1-methylpropyl]amino}-2-(trifluoromethyl)benzonitrile | 821777-80-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-{[(1S)-1-methylpropyl]amino}-2-(trifluoromethyl)benzonitrile
• 英文别名: 4-(S)-sec-butylamino-2-trifluoromethyl-benzonitrile；4-{[(2S)-Butan-2-yl]amino}-2-(trifluoromethyl)benzonitrile；4-[[(2S)-butan-2-yl]amino]-2-(trifluoromethyl)benzonitrile
• CAS: 821777-80-4
• 化学式: C₁₂H₁₃F₃N₂
• 分子量: 242.244
• InChiKey: PWUVHGJXVZNBHT-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Chemical compounds
  申请人：Blanc E. Jean-Baptiste

  公开号：US20060148893A1

  公开（公告）日：2006-07-06

  This invention relates to non-steroidal compounds that are or are believed to be modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

  本发明涉及非类固醇化合物，其是或被认为是雄激素、糖皮质激素、矿物质皮质激素和孕激素受体的调节剂，以及制备和使用此类化合物的方法。
• Benzonitrile Derivatives to Treat Musculoskeletal Frailty
  申请人：Gant G. Thomas

  公开号：US20080045504A1

  公开（公告）日：2008-02-21

  This invention relates to novel amino substituted benzonitrile derivatives and to pharmaceutical compositions containing the novel amino substituted benzonitrile derivatives. This invention also relates to methods of treatment using amino substituted benzonitrile derivatives to prevent and/or restore age-related decline in muscle mass and strength, treat a wasting disease, treat a condition that prevents with low bone mass, increase muscle mass, increase lean body mass, decrease fat body mass, and treat bone fracture and muscle damage in mammals, including humans.

  本发明涉及新颖的氨基取代苯腈衍生物以及含有这些新颖的氨基取代苯腈衍生物的制药组合物。本发明还涉及使用氨基取代苯腈衍生物的治疗方法，以预防和/或恢复肌肉质量和力量的年龄相关下降，治疗消耗性疾病，治疗低骨量状况，增加肌肉质量，增加瘦体重，减少脂肪体重，并治疗哺乳动物，包括人类的骨折和肌肉损伤。
• ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1654221A2

  公开（公告）日：2006-05-10
• [EN] ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS<br/>[FR] COMPOSES CHIMIQUES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2005000795A2

  公开（公告）日：2005-01-06

  This invention relates to aniline derived non-steroidal compounds that are or are believed to be modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
• [EN] THERAPEUTIC COMBINATIONS COMPRISING A SELECTIVE ESTROGEN RECEPTOR MODULATOR AND A SELECTIVE ANDROGEN RECEPTOR MODULATOR<br/>[FR] COMBINAISONS THERAPEUTIQUES COMPRENANT UN MODULATEUR SELECTIF DU RECEPTEUR D'OESTROGENES ET UN MODULATEUR SELECTIF DU RECEPTEUR D'ANDROGENES
  申请人：PFIZER PROD INC

  公开号：WO2006024931A2

  公开（公告）日：2006-03-09

  This invention relates to a pharmaceutical combination of a selective estrogen receptor modulator (SERM) and a selective androgen receptor modulator (SARM). Particularly, this invention relates to a pharmaceutical composition comprising cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-5,6,7,8­tetrahydronapthalene-2-ol, or a pharmaceutically acceptable salt thereof; and a selective androgen receptor modulator. This invention also relates to methods of treatment using the pharmaceutical composition comprising cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-5,6,7,8-tetrahydronapthalene­2-ol, or a pharmaceutically acceptable salt thereof; and a selective androgen receptor modulator. Particularly, this invention is directed to methods to prevent and/or restore age-related decline in muscle mass and strength, treat a wasting disease, treat a condition that prevents with low bone mass, increase muscle mass, increase lean body mass, decrease fat body mass, treat bone fracture and muscle damage and treat female sexual dysfunction in mammals, including humans.