[3-[di(propan-2-yl)carbamoyloxy]phenyl] N,N-di(propan-2-yl)carbamate | 1126310-28-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [3-[di(propan-2-yl)carbamoyloxy]phenyl] N,N-di(propan-2-yl)carbamate
• CAS: 1126310-28-8
• 化学式: C₂₀H₃₂N₂O₄
• 分子量: 364.485
• InChiKey: PBGQKYWLEURRTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [3-[di(propan-2-yl)carbamoyloxy]phenyl] N,N-di(propan-2-yl)carbamate 在 lithium chloride 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Lithium Diisopropylamide-Mediated Ortholithiations: Lithium Chloride Catalysis

  摘要：

  Ortholithiations of a range of arenes mediated by lithium dilsopropylamide (LDA) in THF at -78 degrees C reveal substantial accelerations by as little as 0.5 mol % of LiCl (relative to LDA). Substrate dependencies suggest a specific range of reactivity within which the LiCl catalysis is optimal. Standard protocols with unpurified commercial samples of n-butyllithium to prepare LDA or commercially available LDA show marked batch-dependent rates-up to 100-fold-that could prove significant to the unwary practitioner. Other lithium salts elicit more modest accelerations. The mechanism is not discussed.

  DOI：

  10.1021/jo802713y