1-(3,3-Dimethylbutyl)-6-methoxy-1h-benzimidazole | 824427-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(3,3-Dimethylbutyl)-6-methoxy-1h-benzimidazole
• 英文别名: 1-(3,3-dimethylbutyl)-6-methoxybenzimidazole
• CAS: 824427-48-7
• 化学式: C₁₄H₂₀N₂O
• 分子量: 232.32
• InChiKey: MGYGRLBMVHHQMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Opthalmic compositions for treating ocular hypertension
  申请人：Chen Meng Hsin

  公开号：US20060148805A1

  公开（公告）日：2006-07-06

  This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

  本发明涉及在治疗青光眼和其他导致患者眼内压升高的情况中使用强效钾通道阻滞剂或其配方。本发明还涉及使用这些化合物为哺乳动物，特别是人类的眼提供神经保护效应。
• OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION
  申请人：Merck & Co., Inc.

  公开号：EP1646614A2

  公开（公告）日：2006-04-19
• EP1646614A4
  申请人：——

  公开号：EP1646614A4

  公开（公告）日：2008-09-10
• [EN] OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION<br/>[FR] COMPOSITIONS OPHTALMIQUES DESTINEES AU TRAITEMENT D'HYPERTENSION OCULAIRE
  申请人：MERCK & CO INC

  公开号：WO2005002520A2

  公开（公告）日：2005-01-13

  This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.