6,7,8,14-Tetradehydro-4,5alpha-epoxy-3,6-dimethoxy-17-methylmorphinan acetate | 78619-37-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 6,7,8,14-Tetradehydro-4,5alpha-epoxy-3,6-dimethoxy-17-methylmorphinan acetate
• 英文别名: (4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline;acetic acid
• CAS: 78619-37-1
• 化学式: C21H25NO5
• 分子量: 371.4
• InChiKey: IPHPUWXFGIFNTP-JFYDKBSOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.52
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  68.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Compositions and methods for producing benzylisoquinoline alkaloids
  申请人：California Institute of Technology

  公开号：US10240175B2

  公开（公告）日：2019-03-26

  The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise one, two or more heterologous coding sequences wherein each of the heterologous coding sequences encodes an enzyme involved in the metabolic pathway of a benzylisoquinoline, or its precursors or intermediates from a starting compound. The invention also relates to methods of producing the benzylisoquinoline, as well as select precursors and intermediates thereof by culturing the host cells under culture conditions that promote expression of the enzymes that produce the benzylisoquinoline or precursors or intermediates thereof.

  本发明涉及可产生苄基异喹啉类化合物及其特定前体和中间体的宿主细胞。宿主细胞包括一个、两个或多个异源编码序列，其中每个异源编码序列编码一种酶，该酶参与从起始化合物到苄基异喹啉或其前体或中间体的代谢途径。本发明还涉及在促进产生苄基异喹啉或其前体或中间体的酶的表达的培养条件下培养宿主细胞，从而生产苄基异喹啉及其精选前体和中间体的方法。
• COMPOSITIONS AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS
  申请人：Smolke D. Christina

  公开号：US20080176754A1

  公开（公告）日：2008-07-24

  The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise one, two or more heterologous coding sequences wherein each of the heterologous coding sequences encodes an enzyme involved in the metabolic pathway of a benzylisoquinoline, or its precursors or intermediates from a starting compound. The invention also relates to methods of producing the benzylisoquinoline, as well as select precursors and intermediates thereof by culturing the host cells under culture conditions that promote expression of the enzymes that produce the benzylisoquinoline or precursors or intermediates thereof.
• US8975063B2
  申请人：——

  公开号：US8975063B2

  公开（公告）日：2015-03-10
• US9322039B2
  申请人：——

  公开号：US9322039B2

  公开（公告）日：2016-04-26
• US9376696B1
  申请人：——

  公开号：US9376696B1

  公开（公告）日：2016-06-28