N-benzyl-2-tert-butyl-5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamide | 440121-51-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-benzyl-2-tert-butyl-5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamide
• 英文别名: N-benzyl-2-tert-butyl-5-hydroxy-4-methyl-3-oxo-1H-isoindole-1-carboxamide
• CAS: 440121-51-7
• 化学式: C₂₁H₂₄N₂O₃
• 分子量: 352.433
• InChiKey: ZNWAZTVSBXOQEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  But-2-ynoic acid (benzylcarbamoyl-furan-2-yl-methyl)-tert-butyl-amide 在 ytterbium(III) triflate 作用下， 以 1,4-二氧六环 为溶剂， 以81%的产率得到N-benzyl-2-tert-butyl-5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamide
  参考文献：
  名称：

  Studies on the sequential multi-component coupling/Diels–Alder cycloaddition reaction

  摘要：

  The synthesis of highly functionalized oxabicyclo[2.2.1]heptadiene derivatives through the sequential Use of all Ugi or Passerini multi-component coupling reaction followed by an intramolecular acetylene/furan Diels-Alder reaction was investigated. The nature of the heteroatom in the tether was determined to play a critical role. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02299-7

文献信息

• NEW COMPOUNDS I/418
  申请人：Bjore Annika

  公开号：US20080015237A1

  公开（公告）日：2008-01-17

  There is provided compounds of formula I, wherein R 1 to R 7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

  提供了式I的化合物， 其中R1至R7在描述中给出了它们的含义，这些化合物在预防和治疗心律失常方面非常有用，特别是房性和室性心律失常。
• ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS
  申请人：AstraZeneca AB

  公开号：EP2049484A1

  公开（公告）日：2009-04-22
• Isoindoline Derivatives For The Treatment Of Arrhythmias
  申请人：Bjore Annika

  公开号：US20100298392A1

  公开（公告）日：2010-11-25

  There is provided compounds of formula I, wherein R 1 to R 7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
• [EN] ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS<br/>[FR] DÉRIVÉS D'ISOINDOLINE DANS LE TRAITEMENT DES ARYTHMIES
  申请人：ASTRAZENECA AB

  公开号：WO2008008022A1

  公开（公告）日：2008-01-17

  [EN] There is provided compounds of formula I, wherein R¹ to R⁷ have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
  [FR] La présente invention concerne des composés de formule I, où R¹ à R⁷ ont les valeurs données dans la description, qui peuvent être employés dans le traitement prophylactique et thérapeutique des arythmies, en particulier des arythmies auriculaires et ventriculaires.
• Studies on the sequential multi-component coupling/Diels–Alder cycloaddition reaction
  作者：Dennis L. Wright、Claude V. Robotham、Khalil Aboud

  DOI：10.1016/s0040-4039(01)02299-7

  日期：2002.2

  The synthesis of highly functionalized oxabicyclo[2.2.1]heptadiene derivatives through the sequential Use of all Ugi or Passerini multi-component coupling reaction followed by an intramolecular acetylene/furan Diels-Alder reaction was investigated. The nature of the heteroatom in the tether was determined to play a critical role. (C) 2002 Elsevier Science Ltd. All rights reserved.