6-amino-4-methoxy-nicotinic acid methyl ester | 397309-41-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-amino-4-methoxy-nicotinic acid methyl ester
• 英文别名: Methyl 6-amino-4-methoxynicotinate；methyl 6-amino-4-methoxypyridine-3-carboxylate
• CAS: 397309-41-0
• 化学式: C₈H₁₀N₂O₃
• 分子量: 182.179
• InChiKey: DQOYBIMQEGLGHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  74.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-amino-4-methoxy-nicotinic acid methyl ester 在 碘 、 silver trifluoroacetate 作用下， 以 甲醇 为溶剂， 反应 48.0h， 以59%的产率得到6-amino-5-iodo-4-methoxy-nicotinic acid methyl ester
  参考文献：
  名称：

  [EN] AZAINDOLE COMPOUNDS AS KINASE INHIBITORS
  [FR] COMPOSÉS D'AZAINDOLE EN TANT QU'INHIBITEURS DE KINASE

  摘要：

  本发明涉及一种新型的氮杂吲哚化合物，其为激酶抑制剂，涉及其制备方法、中间体和包含它们的制药组合物。

  公开号：

  WO2004099205A1
• 作为产物：
  描述：

  2-氨基-4-甲氧基吡啶 在 N-碘代丁二酰亚胺 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 20.0~100.0 ℃ 、689.49 kPa 条件下， 反应 32.0h， 生成 6-amino-4-methoxy-nicotinic acid methyl ester
  参考文献：
  名称：

  [EN] IMIDAZO[1,2-A]PYRIDINE DERIVATIVES
  [FR] DÉRIVÉS D'IMIDAZO[1,2-A]PYRIDINE

  摘要：

  The current invention relates to compounds of the formula (I) wherein the substituents are as defined in claim 1, to processes and methods for preparing compounds of formula (I), to agrochemical compositions comprising compounds of formula (I) as defined in claim 1, to preparation of these compositions and to the use of the compounds or compositions in agriculture or horticulture for combating, preventing or controlling infestation of plants, harvested food crops, seeds or non-living materials by phytopathogenic microorganisms, in particular fungi.

  公开号：

  WO2023061838A1

文献信息

• Azaindole compounds as kinase inhibitors
  申请人：David Laurent

  公开号：US20060287354A1

  公开（公告）日：2006-12-21

  The present invention relates to novel azaindole compounds which are kinase inhibitors, methods for their preparation intermediates and pharmaceutical compositions comprising them.

  本发明涉及一种新型的氮杂吲哌化合物，它们是激酶抑制剂，包括它们的制备方法、中间体和制剂。
• Novel Heteroaryl Substituted Imidazo [1,2-A] Pyridine Derivatives
  申请人：Vallin Michaela

  公开号：US20100092385A1

  公开（公告）日：2010-04-15

  The present invention relates to novel heteroaryl substituted imidazopyridine derivatives, precursors thereof, and therapeutic uses of such compounds, having the structural formula (Ia) and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted imidazopyridine derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents.

  本发明涉及新型杂环芳基取代咪唑吡啶衍生物、其前体物以及这些化合物的治疗用途，具有结构式(Ia)，以及它们的药物可接受的盐、组成物和使用方法。此外，本发明还涉及新型杂环芳基取代咪唑吡啶衍生物，适用于在活体患者中成像淀粉样沉积物，它们的组成物、使用方法以及制备这些化合物的过程。更具体地说，本发明涉及在体成像脑中的淀粉样沉积物，以便进行阿尔茨海默病的临床前诊断，以及测量阿尔茨海默病治疗剂的临床疗效的方法。
• HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1309565A1

  公开（公告）日：2003-05-14
• NOVEL HETEROARYL SUBSTITUTED IMIDAZO Ý1,2 -A¨PYRIDINE DERIVATIVES
  申请人：AstraZeneca AB

  公开号：EP2125800A1

  公开（公告）日：2009-12-02
• [EN] HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS<br/>[FR] ESTERS DE MUTILINE HETEROCYCLIQUES ET LEUR UTILISATION EN TANT QU'AGENTS ANTIBACTERIENS
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2002012199A1

  公开（公告）日：2002-02-14

  Pleuromutilin compounds of formula (I), (II) in which: R1 is: a 5- or 6-membered aromatic or heteroaromatic ring attached via a ring carbon atom, preferably pyridyl, and comprising a substituent selected from halo, R?7O-, R7S- or R8R9¿N- on a ring carbon adjacent to the carbon of attachment; or a 5- or 6-membered dihydro heteroaromatic ring attached via a ring carbon atom and comprising one oxygen or one or two nitrogen atoms and optionally fused to phenyl, a 5- or 6-membered heteroaryl ring comprising one or two nitrogen atoms or a 5- or 6-membered heterocyclyl ring comprising a sulphur, oxygen or nitrogen atom and further comprising a substituent selected from oxo or thioxo on a ring carbon adjacent to the carbon of attachment; a 6-membered tetrahydro heteroaromatic ring attached via a ring carbon atom comprising one or two nitrogen atoms and further comprising two substituents independently selected from oxo or thioxo wherein one of the substituents is on a ring carbon adjacent to the carbon of attachment; or a bicyclic heteroyaryl ring attached via a ring carbon atom and comprising nine or ten ring atoms and from one to four nitrogen atoms; wherein the ring of R1 may be optionally further substituted; R2 is vinyl or ethyl; R3 is H, OH or F and R4 is H, or R3 is H and R4 is F and R?5 and R6¿ together form an oxo group; or R?3 and R4¿ is each H and R5 is H, or OH and R6 is H or H5 is H and R6 is H or OH; R7 is optionally substituted C¿(1-6)?alkyl; and R?8 and R9¿ are independently selected from hydrogen or optionally substituted C¿(1-6)?alkyl, present antibacterial activity.