2,4-Dichloro-6-iodopyrimidine | 1062608-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,4-Dichloro-6-iodopyrimidine
• CAS: 1062608-49-4
• 化学式: C₄HCl₂IN₂
• 分子量: 274.87
• InChiKey: WDAKSFIAMFFQAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME
  申请人：SHANGHAI NICHEM FINE CHEMICAL CO., LTD.

  公开号：US20200274070A1

  公开（公告）日：2020-08-27

  Provided are a novel compound and an organic electronic device using the same. The novel compound is represented by the following Formula (I): wherein *b is bonded to one of *a1 and a2*, and *c is bonded to the other of *a1 and a2*; L 1 to L 2 are each independently an arylene group having 6 to 60 ring carbon atoms; Y 1 is selected from the group consisting of: a hydrogen atom, a deuterium atom, an alkyl group having 1 to 12 carbon atoms, and an aryl group having 6 to 30 ring carbon atoms; and m1 to m2 are each independently an integer 0 or 1.

  提供了一种新型化合物和使用该化合物的有机电子器件。该新型化合物由以下式（I）表示：其中*b与*a1和a2*中的一个结合，*c与*a1和a2*中的另一个结合；L1到L2分别独立地是具有6到60个环状碳原子的芳基基团；Y1从以下组成的组中选择：氢原子、氘原子、具有1到12个碳原子的烷基基团和具有6到30个环状碳原子的芳基基团；m1到m2分别独立地是整数0或1。
• [EN] MANUFACTURING PROCESS FOR PYRIMIDINE DERIVATIVES<br/>[FR] PROCÉDÉ DE FABRICATION DE DÉRIVÉS DE PYRIMIDINE
  申请人：NOVARTIS AG

  公开号：WO2012044727A2

  公开（公告）日：2012-04-05

  The invention relates to processes for manufacturing a compound of formula (5) or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of said solid forms for the therapeutic treatment of warm-blooded animals.

  本发明涉及制造化合物式（5）或其立体异构体、互变异构体或盐的过程，其中取代基如规范中所定义。本发明还涉及化合物A及其盐的特定固态形式的新制造工艺，以及使用所述固态形式治疗温血动物的方法。
• [EN] NEW 2, 4-DIANILINOPYRIMIDINES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF ESSENTIALLY AS IKK INHIBITORS<br/>[FR] NOUVEAUX DERIVES DE 2, 4-DIANILINOPYRIMIDINES, LEUR PREPARATION, A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOTAMMENT COMME INHIBITEURS DE IKK
  申请人：SANOFI AVENTIS

  公开号：WO2008099072A2

  公开（公告）日：2008-08-21

  (EN) The invention relates to products of the formula (I) in which : one of R2, R3 and R4 is HaI or CF3 while the other two are H, HaI or alkyl and alkoxy optionally substituted by one or more HaI; R1 is H, cycloalkyl, alkyl, alkenyl or alkynyl, all optionally substituted; A is a simple bond or -CH2-CO-NR6-, with Rβ being selected from the values of R1; the cycle containing Y (or (Y) cycle) being monocyclic or bicyclic and including 4 to 10 links with Y representing O, S, SO, SO2, N-R7 (the (Y) cycle may include a carbonated bridge), C=O or the dioxolanne thereof, CF2, CH-OR8, CH-NR8R9; and R7 being hydrogen, cycloalkyl, alkyl, CH2-alkenyl or CH2- alkynyl, optionally substituted; R8 is hydrogen, alkyl, cycloalkyl ou heterocycloalkyl optionally substituted. The invention relates to said products under all their isomeric forms and to their salts, as drugs essentially used as IKK inhibitors.(FR) L'invention concerne les produits de formule (I) : dans laquelle R2, R3 et R4, représente l'un HaI ou CF3 et les deux autres, H, HaI ou alkyle et alcoxy éventuellement substitués par un ou plusieurs HaI; R1 représente H, cycloalkyle, alkyle, alkényle ou alkynyle, tous éventuellement substitués; A représente simple liaison ou -CH2-CO-NR6- avec Rβ est choisi parmi les valeurs de R1; le cycle renfermant Y (ou cycle (Y) ) étant monocyclique ou bicyclique, constitué de 4 à 10 chaînons avec Y représente O, S, SO, SO2, N-R7 (cycle (Y) pouvant renfermant un pont carboné), C=O ou son dioxolanne, CF2, CH-OR8, CH-NR8R9; et R7 représente hydrogène, cycloalkyle, alkyle, CH2-alkényle ou CH2- alkynyle, éventuellement substitués; R8 représente hydrogène, alkyle, cycloalkyle ou hétérocycloalkyle éventuellement substitués; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments notamment comme inhibiteurs de IKK.