Morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-, hydriodide | 630-82-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: Morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-, hydriodide
• 英文别名: (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;hydroiodide
• CAS: 630-82-0；6202-09-1
• 化学式: C17H22INO3
• 分子量: 415.27
• InChiKey: UJNHNFQTQXGTFC-VYKNHSEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.04
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  52.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• (+)-MORPHINANIUM N-OXIDES AND PROCESSES FOR THEIR PRODUCTION
  申请人：Mallinckrodt LLC

  公开号：EP2398806A1

  公开（公告）日：2011-12-28
• (+)-Morphinanium N-Oxides and Processes for their Production
  申请人：Cantrell Gary L.

  公开号：US20100216997A1

  公开（公告）日：2010-08-26

  The present invention provides (+)-morphinanium N-oxide compounds or pharmaceutically acceptable salts thereof. The invention also provides processes for producing (+)-morphinanium N-oxides or pharmaceutically acceptable salts thereof from the corresponding tertiary N-substituted (+)-morphinan compound or pharmaceutically acceptable salt thereof.
• US8563727B2
  申请人：——

  公开号：US8563727B2

  公开（公告）日：2013-10-22
• [EN] (+)-MORPHINANANIUM N-OXIDES AND PROCESSES FOR THEIR PRODUCTION<br/>[FR] (+)-MORPHINANE N-OXYDES ET PROCÉDÉS DE PRÉPARATION
  申请人：MALLINCKRODT INC

  公开号：WO2010096790A1

  公开（公告）日：2010-08-26

  The present invention provides (+)-morphinanium N-oxide compounds or pharmaceutically acceptable salts thereof. The invention also provides processes for producing (+)-morphinanium N-oxides or pharmaceutically acceptable salts thereof from the corresponding tertiary N-substituted (+)-morphinan compound or pharmaceutically acceptable salt thereof.