1-Methyl-3-(1-methyl-pyrrol-2-yliden)-pyrrolidin-2-on | 5291-79-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-Methyl-3-(1-methyl-pyrrol-2-yliden)-pyrrolidin-2-on
• 英文别名: 2'-Oxo-2,3'-dimethyl-2,3'-diaza-bicyclopentyliden；1-Methyl-3-<1-methyl-pyrrolidinyliden-(2)>-pyrrolidon-(2)；1,1'-dimethyl-hexahydro-[2,3']bipyrrolyliden-2'-one；(3Z)-1-methyl-3-(1-methylpyrrolidin-2-ylidene)pyrrolidin-2-one
• CAS: 5291-79-2
• 化学式: C₁₀H₁₆N₂O
• 分子量: 180.25
• InChiKey: GCUUDFHFMMVHJY-HJWRWDBZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Methyl-3-(1-methyl-pyrrol-2-yliden)-pyrrolidin-2-on 在 钯 lithium aluminium tetrahydride 、 氢气 作用下， 生成 1,1'-dimethyl-2,3'-bipyrrolidinyl
  参考文献：
  名称：

  Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: Affinity for neuronal nicotinic acetylcholine receptors

  摘要：

  A novel pyridine derivative, 3,5-bis-(1-methyl-pyrrolidin-2-yl)-pyridine, and a pair of diastereomers of 1,1'-dimethyl-[2,3]bipyrrolidinyl were isolated from the root of Nicotiana tabacum plants and identified as novel alkaloids by GC-MS analysis. The structures of these new alkaloids were confirmed by total synthesis. The affinities of these novel alkaloids, and other structurally related compounds for alpha L beta 2*, alpha 7* neuronal nicotinic acetylcholine receptors (nAChRs), and for nAChRs mediating nicotine-evoked dopamine release from rat striatum were also assessed. The results indicate that these compounds do not interact with alpha 7* nAChRs, but inhibit [H-3]nicotine binding to the alpha 4 beta 2* nAChR subtype. The results also demonstrate that these compounds act as antagonists at nAChRs mediating nicotine-evoked dopamine release from rat striatum. (c) 2005 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.lfs.2005.09.009
• 作为产物：
  描述：

  N-甲基吡咯烷酮 在 三氯氧磷 、 水 作用下， 生成 1-Methyl-3-(1-methyl-pyrrol-2-yliden)-pyrrolidin-2-on
  参考文献：
  名称：

  Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: Affinity for neuronal nicotinic acetylcholine receptors

  摘要：

  A novel pyridine derivative, 3,5-bis-(1-methyl-pyrrolidin-2-yl)-pyridine, and a pair of diastereomers of 1,1'-dimethyl-[2,3]bipyrrolidinyl were isolated from the root of Nicotiana tabacum plants and identified as novel alkaloids by GC-MS analysis. The structures of these new alkaloids were confirmed by total synthesis. The affinities of these novel alkaloids, and other structurally related compounds for alpha L beta 2*, alpha 7* neuronal nicotinic acetylcholine receptors (nAChRs), and for nAChRs mediating nicotine-evoked dopamine release from rat striatum were also assessed. The results indicate that these compounds do not interact with alpha 7* nAChRs, but inhibit [H-3]nicotine binding to the alpha 4 beta 2* nAChR subtype. The results also demonstrate that these compounds act as antagonists at nAChRs mediating nicotine-evoked dopamine release from rat striatum. (c) 2005 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.lfs.2005.09.009

文献信息

• MODIFIED POLYMER COMPOSITIONS
  申请人：Styron Europe GmbH

  公开号：EP2516478B1

  公开（公告）日：2014-06-11
• US8921502B2
  申请人：——

  公开号：US8921502B2

  公开（公告）日：2014-12-30
• [EN] MODIFIED POLYMER COMPOSITIONS<br/>[FR] COMPOSITIONS DE POLYMÈRE MODIFIÉ
  申请人：STYRON EUROPE GMBH

  公开号：WO2011076377A1

  公开（公告）日：2011-06-30

  The invention provides a first composition comprising at least the following: i) a modified polymer comprising at least one branched modified polymer macromolecule (b1) and at least one linear modified polymer macromolecule (a1), and wherein the at least one branched modified polymer macromolecule and the at least one linear modified polymer macromolecule each, independently, comprises at least one amine group selected from the group consisting of formulas (1A-1F), each as described above: and combinations thereof; and wherein the at least one branched modified polymer macromolecule further comprises one of the structures (ib1 -ib4) as described above, and the at least one linear modified polymer macromolecule further comprises one of the structures (iib1) as described above (see Formula 3A)