5-Chloro-2,4-di-t-butylpyrimidin | 69050-88-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-Chloro-2,4-di-t-butylpyrimidin
• 英文别名: 2,4-di-tert-butyl-5-chloro-pyrimidine；2,4-Ditert-butyl-5-chloropyrimidine
• CAS: 69050-88-0
• 化学式: C₁₂H₁₉ClN₂
• 分子量: 226.749
• InChiKey: FEVLHZKUXPNSAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof
  申请人：Beijing Tide Pharmaceutical Co., Ltd.

  公开号：US10329282B2

  公开（公告）日：2019-06-25

  The present invention relates to a Rho-associated protein kinase inhibitor of Formula (I), a pharmaceutical composition comprising the same, a preparation method thereof, and use thereof for the prevention or treatment of a disease mediated by the Rho-associated protein kinase (ROCK).

  本发明涉及一种式（I）的Rho相关蛋白激酶抑制剂、一种包含其的药物组合物、其制备方法以及其用于预防或治疗由Rho相关蛋白激酶（ROCK）介导的疾病的用途。
• RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF
  申请人：BEIJING TIDE PHARMACEUTICAL CO., LTD.

  公开号：US20190276440A1

  公开（公告）日：2019-09-12

  The present invention relates to a Rho-associated protein kinase inhibitor of formula (I), a pharmaceutical composition comprising the same, a preparation method thereof, and a use of the same in preventing or treating a disease mediated by Rho-associated protein kinase (ROCK).
• METHOD FOR TREATING FATTY LIVER DISEASE AND/OR STEATOHEPATITIS
  申请人：BEIJING TIDE PHARMACEUTICAL CO., LTD.

  公开号：US20220378743A1

  公开（公告）日：2022-12-01

  The present invention falls within the field of biological medicine, and specifically relates to a method for preventing, alleviating and/or treating fatty liver disease and/or steatohepatitis. The method comprises administering, to an individual in need thereof, an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt, an ester, a stereoisomer, a polymorph, a solvate, an N-oxide, an isotopically labeled compound, a metabolite or a prodrug thereof.