(E)-2-(2-thienyl)-1-ethenyl-N,N,N',N'-tetraisopropylphosphonodiamide | 1145788-10-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: (E)-2-(2-thienyl)-1-ethenyl-N,N,N',N'-tetraisopropylphosphonodiamide
• CAS: 1145788-10-8
• 化学式: C₁₈H₃₃N₂OPS
• 分子量: 356.513
• InChiKey: BCDXESPHATUKOJ-VAWYXSNFSA-N

物化性质

• 沸点：
  431.5±47.0 °C(predicted)
• 密度：
  1.043±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  N,N,N',N'-tetraisopropyl-P-[(2RS,3RS)-3-(2-thienyl)-2-(trimethylsilyl)oxiran-2-yl]phosphonothioic diamide 在 双(三甲基硅基)过氧化物 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.5h， 生成 (E)-2-(2-thienyl)-1-ethenyl-N,N,N',N'-tetraisopropylphosphonodiamide
  参考文献：
  名称：

  A stereoselective synthetic entry to β-substituted α-[(trans)-vinyl] phosphonamides

  摘要：

  alpha-(trans-Vinyl) phosphonamides with different substituents at the beta-position were stereoselectively synthesized in high yields by treatment of beta-substituted alpha-epoxy-alpha-trimethylsilyl phosphines with oxidizing agents. The corresponding phosphonamides were unstable in most cases and underwent reductive elimination affording desilylated vinyl derivatives. In turn, alpha-epoxy phosphines resulted from the [1 + 2] addition of [bis(diisopropylamino)phosphino](trimethylsilyl)carbene 2 to aliphatic, aromatic, and heteroaromatic aldehydes. In this way, a great variety of vinyl Compounds have been efficiently prepared through one-pot procedure. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.01.074