N-allyl-N-(5,5,5-trifluoro-4-hydroxy-2-pentynyl)tosylamide | 384836-20-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-allyl-N-(5,5,5-trifluoro-4-hydroxy-2-pentynyl)tosylamide
• CAS: 384836-20-8
• 化学式: C₁₅H₁₆F₃NO₃S
• 分子量: 347.358
• InChiKey: VBXYKRQPVIGSCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  57.61
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N-allyl-N-(5,5,5-trifluoro-4-hydroxy-2-pentynyl)tosylamide 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以90%的产率得到N-allyl-N-(5,5,5-trifluoro-4-oxo-2-pentynyl)tosylamide
  参考文献：
  名称：

  Scope and limitation of intramolecular Pauson–Khand reaction of fluorine-containing enynes

  摘要：

  Intramolecular Pauson-Khand reaction of various fluorine-containing enynes was investigated under various conditions. The reaction of the substrates. which have fluorine atom(s) or fluorine-containing group(s) attached to alkenyl moiety, gave the corresponding cyclopentenones in low to moderate yield, while that of the substrates bearing fluorine-containing groups attached to alkynyl moiety afforded the corresponding cyclopentenones in low to high yield. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(01)00436-5
• 作为产物：
  描述：

  N-tosyl-N-allylpropargylamine 在 正丁基锂 、 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.58h， 生成 N-allyl-N-(5,5,5-trifluoro-4-hydroxy-2-pentynyl)tosylamide 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Scope and limitation of intramolecular Pauson–Khand reaction of fluorine-containing enynes

  摘要：

  Intramolecular Pauson-Khand reaction of various fluorine-containing enynes was investigated under various conditions. The reaction of the substrates. which have fluorine atom(s) or fluorine-containing group(s) attached to alkenyl moiety, gave the corresponding cyclopentenones in low to moderate yield, while that of the substrates bearing fluorine-containing groups attached to alkynyl moiety afforded the corresponding cyclopentenones in low to high yield. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(01)00436-5