1-Benzylpyridin-2-one;hydrochloride | 108575-66-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Benzylpyridin-2-one;hydrochloride
• 英文别名: 1-benzylpyridin-2-one;hydrochloride
• CAS: 108575-66-2
• 化学式: C₁₂H₁₂NO*Cl
• 分子量: 221.686
• InChiKey: ITKOQZJKKHZQPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.27
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  24.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  氯化苄 、 2-羟基吡啶 在 氢氧化钾 作用下， 以 异丙醇 为溶剂， 生成 2-(苄氧基)吡啶 、 1-Benzylpyridin-2-one;hydrochloride
  参考文献：
  名称：

  Rajasekar, N.; Srinivasan, V. S.; Venkatasubramanian, N., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1982, vol. 21, # 8, p. 800 - 802

  摘要：

  DOI：

文献信息

• Preserving compositions containing chitosan and processes for making water soluble O-acetylated chitosan and chitosan
  申请人：——

  公开号：US20020018732A1

  公开（公告）日：2002-02-14

  The present invention is directed to a pharmaceutical preserving composition comprising: (a) at least one chitosan or chitosan derivative and (b) at least one buffer solution, as well as methods of preserving contact lens solutions and disinfecting contact lens using such composition. The present invention is further directed to a method of preparing O-acetylated chitosan or chitosan derivatives comprising the steps of dissolving the chitosan or chitosan derivative into an aqueous acidic solution and reacting the chitosan or chitosan derivative with an acetylating agent in the presence of a phase transfer reagent.

  本发明涉及一种药物保存组合物，包括：(a) 至少一种壳聚糖或壳聚糖衍生物和 (b) 至少一种缓冲溶液，以及使用这种组合物保存隐形眼镜溶液和消毒隐形眼镜的方法。本发明还涉及一种制备 O-乙酰化壳聚糖或壳聚糖衍生物的方法，包括以下步骤：将壳聚糖或壳聚糖衍生物溶解到酸性水溶液中，并在相转移试剂存在下使壳聚糖或壳聚糖衍生物与乙酰化剂反应。
• Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof
  申请人：——

  公开号：US20020177577A1

  公开（公告）日：2002-11-28

  The present invention is directed to a water soluble, randomly substituted partial N-, partial O-acetylated chitosans or chitosan derivatives and methods of preparing water soluble, randomly substituted partial N-, partial O-acetylated chitosans or chitosan derivatives comprising the steps of dissolving the chitosan or chitosan derivative into an aqueous acidic solution and reacting the chitosan or chitosan derivative with an acetylating agent in the presence of a phase transfer reagent. The present invention is further directed to a pharmaceutical preserving composition comprising: (a) at least one chitosan or chitosan derivative and (b) at least one buffer solution, as well as methods of preserving contact lens solutions and disinfecting contact lens using such composition.

  本发明涉及一种水溶性、随机取代的部分N-、部分O-乙酰化壳聚糖或壳聚糖衍生物，以及制备水溶性、随机取代的部分N-、部分O-乙酰化壳聚糖或壳聚糖衍生物的方法，包括以下步骤：将壳聚糖或壳聚糖衍生物溶解到酸性水溶液中，并在相转移试剂存在下使壳聚糖或壳聚糖衍生物与乙酰化剂反应。本发明还涉及一种药物保存组合物，该组合物包含：(a) 至少一种壳聚糖或壳聚糖衍生物和 (b) 至少一种缓冲溶液，以及使用这种组合物保存隐形眼镜溶液和消毒隐形眼镜的方法。
• Water soluble, randomly substituted partial N-, partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof
  申请人：Adjuvant Pharmaceuticals, LLC

  公开号：US20040127461A1

  公开（公告）日：2004-07-01

  The present invention is directed to a water soluble, randomly substituted partial N-, partial O-acetylated chitosans or chitosan derivatives and methods of preparing water soluble, randomly substituted partial N-, partial O-acetylated chitosans or chitosan derivatives comprising the steps of dissolving the chitosan or chitosan derivative into an aqueous acidic solution and reacting the chitosan or chitosan derivative with an acetylating agent in the presence of a phase transfer reagent. The present invention is further directed to a pharmaceutical preserving composition comprising: (a) at least one chitosan or chitosan derivative and (b) at least one buffer solution, as well as methods of preserving contact lens solutions and disinfecting contact lens using such composition.

  本发明涉及一种水溶性、随机取代的部分N-、部分O-乙酰化壳聚糖或壳聚糖衍生物，以及制备水溶性、随机取代的部分N-、部分O-乙酰化壳聚糖或壳聚糖衍生物的方法，包括以下步骤：将壳聚糖或壳聚糖衍生物溶解到酸性水溶液中，并在相转移试剂存在下使壳聚糖或壳聚糖衍生物与乙酰化剂反应。本发明还涉及一种药物保存组合物，该组合物包含：(a) 至少一种壳聚糖或壳聚糖衍生物和 (b) 至少一种缓冲溶液，以及使用这种组合物保存隐形眼镜溶液和消毒隐形眼镜的方法。
• 5-(1-AMINOCYCLOHEXYL)-2(1H)-PYRIDINONE AND RELATED COMPOUNDS
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0487602A1

  公开（公告）日：1992-06-03
• EP0487602A4
  申请人：——

  公开号：EP0487602A4

  公开（公告）日：1993-03-17