1-(O⁵-butyryl-β-D-ribofuranosyl)-1H-[1,2,4]triazole-3-carboxylic acid amide | 58151-88-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 三唑核糖核苷和核糖核苷酸
• 英文名称: 1-(O⁵-butyryl-β-D-ribofuranosyl)-1H-[1,2,4]triazole-3-carboxylic acid amide
• 英文别名: 1-(5'-O-butyryl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide；[(2R,3S,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl butanoate
• CAS: 58151-88-5
• 化学式: C₁₂H₁₈N₄O₆
• 分子量: 314.298
• InChiKey: LPBGJQHYVDNTJH-WOUKDFQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  150
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• US3984396A
  申请人：——

  公开号：US3984396A

  公开（公告）日：1976-10-05
• US6680292B1
  申请人：——

  公开号：US6680292B1

  公开（公告）日：2004-01-20
• [EN] NEURON STIMULATION BY RIBAVIRIN, AND ANALOGS THEREOF<br/>[FR] STIMULATION DE NEURONES PAR RIBAVIRINE, ET SES ANALOGUES
  申请人：SALK INST FOR BIOLOGICAL STUDI

  公开号：WO2000030656A1

  公开（公告）日：2000-06-02

  The present invention is directed to compositions comprising 1-(β-D-ribofuranosyl)-1H-1,2,4-triazole compounds and either endogenous or exogenous neurotrophic factors. Methods of using such compounds and compositions are also provided. In one aspect, the invention provides methods of using invention compositions and compounds to enhance neurite outgrowth, neuronal survival and neuronal proliferation in mammalian cells. In a preferred embodiment, a 1-(β-D-ribofuranosyl)-1H-1,2,4-triazole compound is infused directly to a desired situs. In a more preferred embodiment the 1-(β-D-ribofuranosyl)-1H-1,2,4-triazole compound is administered orally. In another aspect, the invention provides methods of treating a neurological disease in a mammal subject. In a further aspect, the invention provides methods of treating neuronal trauma in a mammal subject.