3-疏基吡啶 | 99780-72-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-疏基吡啶
• 英文名称: 3-mercaptopyridin-2-ylsulfonamide
• 英文别名: 3-Mercaptopyridine-2-sulfonamide；3-sulfanylpyridine-2-sulfonamide
• CAS: 99780-72-0
• 化学式: C₅H₆N₂O₂S₂
• 分子量: 190.247
• InChiKey: XXONZJKORUUFIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-疏基吡啶 、 1-溴-3-氟丙烷 在 盐酸 、 potassium carbonate 作用下， 以 N-甲基乙酰胺 、 正己烷 为溶剂， 生成 吡啶-2-磺酰胺 、 3-(3-fluoropropylthio)pyridin-2-ylsulfonamide
  参考文献：
  名称：

  Pyridyl sulfonylurea herbicides

  摘要：

  N-吡啶磺酰-N'-嘧啶基和-三嗪基脲的化学式I如下：其中R.sub.1为氢、卤素、C.sub.1-C.sub.4烷基、C.sub.1-C.sub.4烷氧基、C.sub.1-C.sub.4烷硫基、C.sub.1-C.sub.4卤代烷氧基或CF.sub.3；R.sub.2为氢或C.sub.1-C.sub.4烷基；A为C.sub.1-C.sub.6烷基或C.sub.3-C.sub.6环烷基，每个都可以通过卤素进行单取代至三取代，或者为C.sub.1-C.sub.4烷基或C.sub.3-C.sub.6环烷基，每个都被C.sub.1-C.sub.4烷氧基、C.sub.1-C.sub.4烷硫基、C.sub.1-C.sub.4烷基磺酰基、C.sub.1-C.sub.4烷基亚砜基、C.sub.2-C.sub.4烯基、C.sub.5-C.sub.6环烯基、氨基、C.sub.1-C.sub.4烷基氨基、C.sub.1-C.sub.4二烷基氨基或C.sub.2-C.sub.4炔基取代，C.sub.2-C.sub.4烯基基团和C.sub.5-C.sub.6环烯基基团可以额外通过卤素进行单取代至三取代；或者A为含有O、N和SO.sub.2的异原子的4-至6元饱和杂环；或者A为被含有O、N和SO.sub.2的异原子的4-至6元饱和杂环取代的C.sub.1-C.sub.4烷基；X为C.sub.1-C.sub.3烷基、通过卤素进行单取代至三取代的C.sub.1-C.sub.3烷基，或者为C.sub.1-C.sub.3烷氧基或通过卤素进行单取代至三取代的C.sub.1-C.sub.3烷氧基；Y为卤素、C.sub.1-C.sub.3烷基、通过卤素进行单取代至三取代的C.sub.1-C.sub.3烷基，或者为C.sub.1-C.sub.3烷氧基、通过卤素进行单取代至三取代的C.sub.1-C.sub.3烷氧基，或者为环丙基、甲基氨基或二甲基氨基；E为氮或甲基基团，这些化合物与胺、碱金属碱或碱土金属碱或季铵碱的盐具有良好的选择性除草性能，早期和后期除草性能以及良好的生长调节性能。

  公开号：

  US05352654A1
• 作为产物：
  描述：

  3-氟-2-吡啶磺酰胺 在 硫酸 、 硫化氢 、 potassium tert-butylate 作用下， 以 N-甲基乙酰胺 、 磷酸酐 为溶剂， 生成 3-疏基吡啶
  参考文献：
  名称：

  Pyridyl sulfonylurea herbicides

  摘要：

  N-吡啶磺酰-N'-嘧啶基和-三嗪基脲的化学式I如下：其中R.sub.1为氢、卤素、C.sub.1-C.sub.4烷基、C.sub.1-C.sub.4烷氧基、C.sub.1-C.sub.4烷硫基、C.sub.1-C.sub.4卤代烷氧基或CF.sub.3；R.sub.2为氢或C.sub.1-C.sub.4烷基；A为C.sub.1-C.sub.6烷基或C.sub.3-C.sub.6环烷基，每个都可以通过卤素进行单取代至三取代，或者为C.sub.1-C.sub.4烷基或C.sub.3-C.sub.6环烷基，每个都被C.sub.1-C.sub.4烷氧基、C.sub.1-C.sub.4烷硫基、C.sub.1-C.sub.4烷基磺酰基、C.sub.1-C.sub.4烷基亚砜基、C.sub.2-C.sub.4烯基、C.sub.5-C.sub.6环烯基、氨基、C.sub.1-C.sub.4烷基氨基、C.sub.1-C.sub.4二烷基氨基或C.sub.2-C.sub.4炔基取代，C.sub.2-C.sub.4烯基基团和C.sub.5-C.sub.6环烯基基团可以额外通过卤素进行单取代至三取代；或者A为含有O、N和SO.sub.2的异原子的4-至6元饱和杂环；或者A为被含有O、N和SO.sub.2的异原子的4-至6元饱和杂环取代的C.sub.1-C.sub.4烷基；X为C.sub.1-C.sub.3烷基、通过卤素进行单取代至三取代的C.sub.1-C.sub.3烷基，或者为C.sub.1-C.sub.3烷氧基或通过卤素进行单取代至三取代的C.sub.1-C.sub.3烷氧基；Y为卤素、C.sub.1-C.sub.3烷基、通过卤素进行单取代至三取代的C.sub.1-C.sub.3烷基，或者为C.sub.1-C.sub.3烷氧基、通过卤素进行单取代至三取代的C.sub.1-C.sub.3烷氧基，或者为环丙基、甲基氨基或二甲基氨基；E为氮或甲基基团，这些化合物与胺、碱金属碱或碱土金属碱或季铵碱的盐具有良好的选择性除草性能，早期和后期除草性能以及良好的生长调节性能。

  公开号：

  US05352654A1

文献信息

• Pyridin-2-yl-sulfonamides useful for the preparation of herbicidally
  申请人：Ciba-Geigy Corporation

  公开号：US05410063A1

  公开（公告）日：1995-04-25

  A compound of the formula II ##STR1## in which R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkoxy or CF.sub.3 and A is C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl, each of which is monosubstituted to trisubstituted by halogen, or is C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.6 cycloalkyl, each of which is substituted by C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.2 -C.sub.4 alkenyl, C.sub.5 -C.sub.6 cycloalkenyl, amino, C.sub.1 -C.sub.4 alkylamino, C.sub.1 -C.sub.4 dialkylamino or C.sub.2 -C.sub.4 alkynyl, it being possible for the C.sub.2 -C.sub.4 alkenyl radical and the C.sub.5 -C.sub.6 cycloalkenyl radical to be additionally monosubstituted to trisubstituted by halogen; or A is a 4- to 6-membered saturated heterocycle which contains a hetero atom selected from the group consisting of O, N and SO.sub.2 ; or A is C.sub.1 -C.sub.4 alkyl which is substituted by a 4- to 6-membered saturated heterocycle which contains a hetero atom selected from the group consisting of O, N and SO.sub.2.

  化合物的化学式为II ##STR1## 其中R.sub.1为氢、卤素、C.sub.1-C.sub.4烷基、C.sub.1-C.sub.4烷氧基、C.sub.1-C.sub.4烷硫基、C.sub.1-C.sub.4卤代烷氧基或CF.sub.3，A为C.sub.1-C.sub.6烷基或C.sub.3-C.sub.6环烷基，每个基团均为单取代至三取代卤素，或者为C.sub.1-C.sub.4烷基或C.sub.3-C.sub.6环烷基，每个基团均为C.sub.1-C.sub.4烷氧基、C.sub.1-C.sub.4烷硫基、C.sub.1-C.sub.4烷基磺酰基、C.sub.1-C.sub.4烷基亚磺酰基、C.sub.2-C.sub.4烯基、C.sub.5-C.sub.6环烯基、氨基、C.sub.1-C.sub.4烷基氨基、C.sub.1-C.sub.4二烷基氨基或C.sub.2-C.sub.4炔基，C.sub.2-C.sub.4烯基基团和C.sub.5-C.sub.6环烯基基团还可以另外单取代至三取代卤素；或A为4-至6-成员饱和杂环，其中包含从O、N和SO.sub.2组成的杂原子；或A为C.sub.1-C.sub.4烷基，该基团被从O、N和SO.sub.2组成的杂原子构成的4-至6-成员饱和杂环取代。
• Pyridyl sulfonylurea herbicides
  申请人：Ciba-Geigy Corporation

  公开号：US05352654A1

  公开（公告）日：1994-10-04

  N-Pyridinesulfonyl-N'-pyrimidinyl- and -triazinylureas of the formula I ##STR1## in which R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 C.sub.4 haloalkoxy or CF.sub.3 ; R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; A is C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl, each of which is monosubstituted to trisubstituted by halogen, or is C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.6 cycloalkyl, each of which is substituted by C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.2 -C.sub.4 alkenyl, C.sub.5 -C.sub.6 cycloalkenyl, amino, C.sub.1 -C.sub.4 alkylamino, C.sub.1 -C.sub.4 dialkylamino or C.sub.2 -C.sub.4 alkynyl, it being possible for the C.sub.2 -C.sub.4 alkenyl radical and the C.sub.5 -C.sub.6 cycloalkenyl radical to be additionally monosubstituted to trisubstituted by halogen; or A is a 4- to 6-membered saturated heterocycle which contains a hetero atom selected from the group comprising O, N and SO.sub.2 ; or A is C.sub.1 -C.sub.4 alkyl which is substituted by a 4- to 6-membered saturated heterocycle which contains a hetero atom selected from the group comprising O, N and SO.sub.2 ; X is C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkyl which is monosubstituted to trisubstituted by halogen, or is C.sub.1 -C.sub.3 alkoxy or C.sub.1 -C.sub.3 alkoxy which is monosubstituted to trisubstituted by halogen; Y is halogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkyl which is monosubstituted to trisubstituted by halogen, or is C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkoxy which is monosubstituted to trisubstituted by halogen, or is cyclopropyl, methylamino or dimethylamino; and E is nitrogen or the methine group, and the salts of these compounds with amines, alkali metal bases or alkaline earth metal bases or with quaternary ammonium bases have good selective herbicidal properties pre-emergence and post-emergence, and good growth-regulating properties.

  N-吡啶磺酰-N'-嘧啶基和-三嗪基脲的化学式I如下：其中R.sub.1为氢、卤素、C.sub.1-C.sub.4烷基、C.sub.1-C.sub.4烷氧基、C.sub.1-C.sub.4烷硫基、C.sub.1-C.sub.4卤代烷氧基或CF.sub.3；R.sub.2为氢或C.sub.1-C.sub.4烷基；A为C.sub.1-C.sub.6烷基或C.sub.3-C.sub.6环烷基，每个都可以通过卤素进行单取代至三取代，或者为C.sub.1-C.sub.4烷基或C.sub.3-C.sub.6环烷基，每个都被C.sub.1-C.sub.4烷氧基、C.sub.1-C.sub.4烷硫基、C.sub.1-C.sub.4烷基磺酰基、C.sub.1-C.sub.4烷基亚砜基、C.sub.2-C.sub.4烯基、C.sub.5-C.sub.6环烯基、氨基、C.sub.1-C.sub.4烷基氨基、C.sub.1-C.sub.4二烷基氨基或C.sub.2-C.sub.4炔基取代，C.sub.2-C.sub.4烯基基团和C.sub.5-C.sub.6环烯基基团可以额外通过卤素进行单取代至三取代；或者A为含有O、N和SO.sub.2的异原子的4-至6元饱和杂环；或者A为被含有O、N和SO.sub.2的异原子的4-至6元饱和杂环取代的C.sub.1-C.sub.4烷基；X为C.sub.1-C.sub.3烷基、通过卤素进行单取代至三取代的C.sub.1-C.sub.3烷基，或者为C.sub.1-C.sub.3烷氧基或通过卤素进行单取代至三取代的C.sub.1-C.sub.3烷氧基；Y为卤素、C.sub.1-C.sub.3烷基、通过卤素进行单取代至三取代的C.sub.1-C.sub.3烷基，或者为C.sub.1-C.sub.3烷氧基、通过卤素进行单取代至三取代的C.sub.1-C.sub.3烷氧基，或者为环丙基、甲基氨基或二甲基氨基；E为氮或甲基基团，这些化合物与胺、碱金属碱或碱土金属碱或季铵碱的盐具有良好的选择性除草性能，早期和后期除草性能以及良好的生长调节性能。