2-[3-({1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]-4-methyl-1H-indol-3-yl}methyl)imidazo[1,2-a]pyridin-2-yl]-1-naphthoic acid | 1258872-94-4

• 分子结构分类: 有机化合物
• 英文名称: 2-[3-({1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]-4-methyl-1H-indol-3-yl}methyl)imidazo[1,2-a]pyridin-2-yl]-1-naphthoic acid
• 英文别名: 2-[3-[[1-[2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl]-4-methylindol-3-yl]methyl]imidazo[1,2-a]pyridin-2-yl]naphthalene-1-carboxylic acid
• CAS: 1258872-94-4
• 化学式: C₃₈H₃₁N₃O₃
• 分子量: 577.682
• InChiKey: VMSLTWMQDASAGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  44
• 可旋转键数：
  7
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  68.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL IMIDAZOPYRIDINE COMPOUND
  申请人：Takeuchi Jun

  公开号：US20120094944A1

  公开（公告）日：2012-04-19

  For the prevention and/or treatment of chymase-mediated diseases such as skin diseases, circulatory diseases, digestive system diseases, respiratory diseases, liver diseases, ocular diseases or the like, a drug is provided having as an active ingredient a compound having extremely strong chymase inhibitory activity, high safety, and high metabolic stability. The compound represented by the formula (I): wherein all symbols have the same meanings as in the description, a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof, is useful as a pharmaceutical ingredient having chymase inhibitory activity for preventing and/or treating of chymase-mediated disease, such as skin diseases, circulatory diseases, digestive system diseases, respiratory diseases, liver diseases, ocular diseases or the like.

  为了预防和/或治疗由钳切酶介导的疾病，如皮肤疾病、循环系统疾病、消化系统疾病、呼吸系统疾病、肝脏疾病、眼部疾病等，提供了一种药物，其活性成分是具有极强的钳切酶抑制活性、高安全性和高代谢稳定性的化合物。该化合物由以下式子表示：其中所有符号的含义与描述中相同，其盐、N-氧化物或溶剂化物，或其前药形式，可用作具有钳切酶抑制活性的药用成分，用于预防和/或治疗由钳切酶介导的疾病，如皮肤疾病、循环系统疾病、消化系统疾病、呼吸系统疾病、肝脏疾病、眼部疾病等。
• US8569504B2
  申请人：——

  公开号：US8569504B2

  公开（公告）日：2013-10-29