Adenosine 5'-monophosphate xsodium salt | 1231926-40-1

• 物质功能分类: 生物化工 - 核苷类药物 - 核苷中间体
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: Adenosine 5'-monophosphate xsodium salt
• CAS: 1231926-40-1；4578-31-8
• 化学式: C10H14N5NaO7P
• 分子量: 370.21
• InChiKey: JWJUYEHEBGNNAE-MCDZGGTQSA-N

物化性质

• 熔点：
  232-235°C
• 溶解度：
  可溶于水中

计算性质

• 辛醇/水分配系数(LogP)：
  -2.24
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  186
• 氢给体数：
  5
• 氢受体数：
  11

制备方法与用途

简介

5'-腺嘌呤核苷酸二钠盐是一种腺苷酸二钠盐。目前国内外技术中，腺苷酸主要通过核酸降解法、化学合成和酶合成制得，在分子结构上通常由腺苷和磷酸构成核苷酸，戊糖和碱基组成核苷，其中磷酸连在糖的第五位碳上，因此称为5’-腺苷酸。5’-腺苷酸含有两个羟基，可以与碱反应生成钠盐，即5’-腺苷酸钠盐，简称腺苷酸钠盐。腺苷酸钠盐广泛应用于食品添加剂及医药中间体中，尤其是腺苷酸二钠盐。

用途

本品为核苷酸类产品，可用于生产核苷酸类药物的中间体、食品添加剂以及生化制品等。

文献信息

• Thermophoresis measurements in nanoliter-droplets
  申请人：Nano Temper Technologies GmbH

  公开号：EP2942103A1

  公开（公告）日：2015-11-11

  The present invention relates generally to a system and a method for thermo-optical measurements in a droplet (23) of aqueous solution comprising particles of interest, the method comprising the following steps: providing the droplet of aqueous solution with a volume of less than 200nl, wherein the aqueous solution is a first liquid (21) and at least a part of the particles of interest are fluorescent particles; embedding the droplet (23) of aqueous solution at least partly in a second liquid (21); irradiating a laser light beam into the droplet to obtain a spatial temperature distribution in the droplet around the irradiated laser light beam; exciting fluorescently said fluorescent particles and detecting the fluorescence at least at one position or at around one position in the droplet or detecting the fluorescence distribution of said fluorescently excited particles, wherein said detection of fluorescence is performed at least once at a predetermined time after the start of the laser irradiation; and determining a characteristic of the particles of interest from the detected fluorescence intensity or fluorescence intensity distribution.

  本发明一般涉及一种系统和一种方法，用于在包含相关颗粒的水溶液液滴（23）中进行热光学测量，该方法包括以下步骤：提供体积小于 200nl 的水溶液液滴，其中水溶液为第一液体 (21)，至少一部分感兴趣的颗粒为荧光颗粒；将水溶液液滴 (23) 至少部分嵌入第二液体 (21)；将激光光束照射到液滴中，以获得照射的激光光束周围液滴中的空间温度分布；激发所述荧光颗粒的荧光，并检测液滴中至少一个位置或周围一个位置的荧光或检测所述荧光激发颗粒的荧光分布，其中所述荧光检测至少在激光照射开始后的预定时间进行一次；以及根据检测到的荧光强度或荧光强度分布确定相关颗粒的特征。
• METHOD OF PRODUCING YEAST EXTRACT
  申请人：Asahi Group Holdings, Ltd.

  公开号：EP3120714A1

  公开（公告）日：2017-01-25

  The present invention provides a method of producing a yeast extract with a high nucleic acid content from yeast cells. The method of producing a yeast extract of the present invention includes: (1) a step of subjecting yeast cells to a heat sterilization at 100 to 130°C for 10 to 90 seconds, (2) a step of preparing a yeast extract by subjecting the yeast cells sterilized in step (1) to an extraction treatment at 50 to 85°C and a pH of 7 to 10, (3) a step, performed after step (2), of subjecting the obtained yeast extract to a solid-liquid separation treatment to remove at least a portion of the insoluble matter, (4) a step, performed after step (3), of subjecting the yeast extract from which the insoluble matter has been removed to a nuclease treatment and a deaminase treatment, and (5) a step, performed after step (4), of subjecting the yeast extract to a heat sterilization treatment.

  本发明提供了一种从酵母细胞中生产核酸含量高的酵母提取物的方法。本发明生产酵母提取物的方法包括：(1)将酵母细胞在100至130℃下加热灭菌10至90秒；(2)将在步骤(1)中灭菌的酵母细胞在50至85℃、pH值为7至10的条件下进行提取处理，制备酵母提取物；(3)在步骤(2)之后进行的步骤、(4) 在步骤(3)之后进行的步骤，即对已去除不溶性物质的酵母提取物进行核酸酶处理和脱氨酶处理，以及 (5) 在步骤(4)之后进行的步骤，即对酵母提取物进行加热灭菌处理。
• Methods and compositions for segregating target nucleic acid from mixed nucleic acid samples
  申请人：FLIR DETECTION, INC.

  公开号：US10190113B2

  公开（公告）日：2019-01-29

  The invention provides methods, compositions and kits for segregating a target nucleic acid from a mixed nucleic acid sample. The methods, compositions and kits comprise a non-processive endonuclease (e.g., a restriction enzyme) or an antibody that binds the target nucleic acid (e.g., has methylation specificity). The mixed nucleic acid sample can comprise prokaryotic and eukaryotic nucleic acid and/or nucleic acid from more than one prokaryotic or eukaryotic organisms.

  本发明提供了从混合核酸样本中分离目标核酸的方法、组合物和试剂盒。这些方法、组合物和试剂盒包括非加工性核酸内切酶（如限制性酶）或结合目标核酸（如具有甲基化特异性）的抗体。混合核酸样本可包括原核生物和真核生物核酸和/或来自一种以上原核生物或真核生物的核酸。
• Methods for modulating taste receptors
  申请人：MARS, INCORPORATED

  公开号：US11185100B2

  公开（公告）日：2021-11-30

  Amino acids present in domains of an umami taste receptor are described herein, wherein the amino acids interact with at least one nucleotide derivative and/or at least one transmembrane compound that potentiates, modulates, increases, and/or enhances the activity of the umami receptor. Such compounds can be used in flavor compositions to enhance the umami taste and/or palatability of food products.

  本文描述了存在于鲜味受体结构域中的氨基酸，其中氨基酸与至少一种核苷酸衍生物和/或至少一种跨膜化合物相互作用，从而增强、调节、增加和/或提高鲜味受体的活性。此类化合物可用于调味组合物，以增强食品的鲜味和/或适口性。
• Polymer composition
  申请人：Terada Takahiko

  公开号：US20050119411A1

  公开（公告）日：2005-06-02

  A flame-retardant polymer composition contains a polymer and a flame retardant, in which the flame retardant includes a polymer having a flame-retardant moiety in a side chain thereof.

  阻燃聚合物组合物包含聚合物和阻燃剂，其中阻燃剂包括在其侧链中具有阻燃分子的聚合物。