4-[[5-(6-methoxy-3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]amino]cyclohexanol | 1206205-79-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-[[5-(6-methoxy-3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]amino]cyclohexanol
• 英文别名: 4-[5-(6-methoxypyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylamino]cyclohexanol；4-[[5-(6-Methoxy-3-pyridyl) imidazo[2,1-b] [1,3,4]thiadiazol-2-yl]amino] cyclohexanol；4-[[5-(6-methoxypyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]amino]cyclohexan-1-ol
• CAS: 1206205-79-9
• 化学式: C₁₆H₁₉N₅O₂S
• 分子量: 345.425
• InChiKey: DRGGGSADCMSJDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• IMIDAZOTHIADIAZOLE DERIVATIVES
  申请人：Hoelzemann Guenter

  公开号：US20110130396A1

  公开（公告）日：2011-06-02

  Novel imidazo[2,1-b][1,3,4]thiadiazole derivatives of formula (I) wherein R 1 and R 2 have the meaning according to claim 1, are inhibitors of TGF-beta receptor I kinase, and can be employed, inter alia, for the treatment of tumors.

  式(I)中的新型咪唑[2,1-b][1,3,4]噻二唑衍生物，其中R1和R2的含义如权利要求1所述，是TGF-beta受体I激酶的抑制剂，可用于治疗肿瘤等疾病。
• Methods, compositions, and uses of novel Fyn kinase inhibitors
  申请人：Lau Warren C.

  公开号：US10688093B2

  公开（公告）日：2020-06-23

  The present invention provides methods for inhibiting Fyn kinase, using 5-3-pyridin-2-amine, 6-3-imidazo[1,2-a] pyrazine, 6-3-imidazo[1,2-b] pyridazine, N-(5-imidazo [2,1-b][1,3,4] thiadiazol-2-yl)-amine, 4-3-1H-pyrazolo[3,4-b] pyridine, and N-(3-imidazo [1,2-b] pyridazin-6-yl) amine compounds and methods of treatment, prevention, inhibition or amelioration of diseases and conditions associated with Fyn kinase using such compounds.

  本发明提供了使用 5-3-吡啶-2-胺、6-3-咪唑并[1,2-a]吡嗪、6-3-咪唑并[1,2-b]哒嗪、N-(5-咪唑并[2,1-b][1,3,4]噻二唑-2-基)胺、4-3-1H-吡唑并[3、4-b]吡啶和 N-(3-咪唑并[1,2-b]哒嗪-6-基)胺化合物，以及使用此类化合物治疗、预防、抑制或改善与 Fyn 激酶相关的疾病和病症的方法。
• IMIDAZOTHIADIAZOLES DERIVATIVES
  申请人：Merck Patent GmbH

  公开号：EP2307425B1

  公开（公告）日：2014-03-26
• METHODS, COMPOSITIONS, AND USES OF NOVEL FYN KINASE INHIBITORS
  申请人：Lau, Warren C.

  公开号：EP3347462A1

  公开（公告）日：2018-07-18
• Methods, Compositions, and Uses of Novel FYN Kinase Inhibitors
  申请人：LAU Warren C.

  公开号：US20180250297A1

  公开（公告）日：2018-09-06

  The present invention provides methods for inhibiting Fyn kinase, using 5-3-pyridin-2-amine, 6-3-imidazo[1,2-a] pyrazine, 6-3-imidazo[1,2-b] pyridazine, N-(5-imidazo [2,1-b][1,3,4] thiadiazol-2-yl)-amine, 4-3-1H-pyrazolo[3,4-b] pyridine, and N-(3-imidazo [1,2-b] pyridazin-6-yl) amine compounds and methods of treatment, prevention, inhibition or amelioration of diseases and conditions associated with Fyn kinase using such compounds.