methyl 4-cyano-2-{[(3R,6R)-1-{[2-fluoro-6-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}pyridine-3-carboxylate | 1604794-89-9

• 分子结构分类: 有机化合物
• 英文名称: methyl 4-cyano-2-{[(3R,6R)-1-{[2-fluoro-6-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}pyridine-3-carboxylate
• 英文别名: methyl 4-cyano-2-[(3R,6R)-1-[2-fluoro-6-(5-methyl-1,2,4-oxadiazol-3-yl)benzoyl]-6-methylpiperidin-3-yl]oxypyridine-3-carboxylate
• CAS: 1604794-89-9
• 化学式: C₂₄H₂₂FN₅O₅
• 分子量: 479.468
• InChiKey: AZBWVAGPGHWBIQ-CZUORRHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  131
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• [EN] 2-PYRIDYLOXY-3-ESTER-4-NITRILE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE TYPE 2-PYRIDYLOXY-3-ESTER-4-NITRILE DES RÉCEPTEURS D'OREXINES
  申请人：MERCK SHARP & DOHME

  公开号：WO2014062533A1

  公开（公告）日：2014-04-24

  The present invention is directed to 2-pyridyloxy-3-ester-4-nitrile compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-3-ester-4-nitrile compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及对俄利新受体拮抗剂的2-吡啶氧基-3-酯基-4-腈类化合物。本发明还涉及所述2-吡啶氧基-3-酯基-4-腈类化合物在治疗或预防神经和精神疾病中的用途，这些疾病中涉及俄利新受体。本发明还涉及含有这些化合物的药物组合物。本发明还涉及这些药物组合物在预防或治疗涉及俄利新受体的疾病中的用途。
• 2-PYRIDYLOXY-3-ESTER-4-NITRILE OREXIN RECEPTOR ANTAGONISTS
  申请人：KUDUK Scott D.

  公开号：US20150252033A1

  公开（公告）日：2015-09-10

  The present invention is directed to 2-pyridyloxy-3-ester-4-nitrile compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-3-ester-4-nitrile compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及2-吡啶氧基-3-酯基-4-腈基化合物，其为促进睡眠激素受体的拮抗剂。本发明还涉及使用所述2-吡啶氧基-3-酯基-4-腈基化合物治疗或预防神经和精神障碍疾病，以及其中涉及促进睡眠激素受体的疾病。本发明还涉及包含这些化合物的制药组合物。本发明还涉及使用这些制药组合物预防或治疗涉及促进睡眠激素受体的疾病。
• EP2908812A1
  申请人：——

  公开号：EP2908812A1

  公开（公告）日：2015-08-26
• US9586950B2
  申请人：——

  公开号：US9586950B2

  公开（公告）日：2017-03-07