3-硝基-N-十八烷基苯甲酰胺 | 109799-65-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-硝基-N-十八烷基苯甲酰胺
• 英文名称: N-Octadecyl m-nitrobenzamide
• 英文别名: 3-nitro-N-octadecylbenzamide
• CAS: 109799-65-7
• 化学式: C25H42N2O3
• mdl: MFCD00043747
• 分子量: 418.6
• InChiKey: MBGMGVISROGRGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  30
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• N-substituted anilines
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0579066A2

  公开（公告）日：1994-01-19

  57 Compounds of the formula wherein R1 is hydrogen or -(CH2)mCOOR2; R2 is hydrogen, (R6)2N(CH2)2-, R6COOCH2- or -CH2CON(CH2CH20H)2; R3 is hydrogen, nitro, hydroxy, amino, CH3(CH2) nS(O)0-2-, CH3(CH2)n-,CH3(CH2)nO- ,R5COO-, RsOOC- ,R5HNCOO-, RsNHCO-, RsCONH-, RsNHCONH-, [CH3(CH2)n]2NCO- , CH3(CH2)nCHOHCH20-, (2-quinolinyl)methoxy, oleyloxy, linoleyloxy, R8OOC(CH2)t-O, (R6 0)2 PO(CH2)pO- , (HO) (R60)PO(CH2)pO- , R6[O(CH2)2]qO- , R7(CH2)pO-, or -O(CH2)p-pyridinium+(OH-); R4 is CH3(CH2) n- , CH3(CH2)nO- , CF3SO2NH-, RsCOO-, RsOOC- ,R5HNCOO-, RsNHCO-, RsCONH-RsNHCONH-, [CH3(CH2)n]2NCO-, CH3(CH2)nCHOHCH20-, carboxy, (2-quinolinyl)methoxy, oleyloxy, linoleyloxy, R8OOC(CH2)tO-, R6[O(CH2)2]qO- , or R7(CH2)pO-; R5 is CH3(CH2)n-, 1-adamantyl or diphenylmethyl; R6 is lower alkyl; R7 is 1- or 2 -naphthyloxy, 1-, 2- or 3-pyridinyloxy, 2,3- or 3,4-dihydroxyphenyl, 6,7-dihydroxy-2-naphthyl, phenyl, phenoxy or substituted phenyl or phenoxy, wherein the substituent is selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, nitro, amino, halo, R6 S(O)0-2-, carboxy, carboxy-lower alkyl or phenyl; R8 is hydrogen or lower alkyl; n is an integer from 0 to 17; m is an integer from 1 to 3; t is an integer from 1 to 10; p is an integer from 2 to 18, and q is an integer from 1 to 6; and when R2 is hydrogen, a pharmaceutically acceptable salt thereof with a base, are potent inhibitors of phospholipases A2 (PLA2's) and are therefore useful in the treatment of inflammatory diseases, such as psosiasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary disease, myocardial ischemia/reperfusion, and trauma induced inflammation, such as spinal cord injury.

  57 式中的化合物 式中 R1 是氢或-(CH2)mCOOR2； R2 是氢、(R6)2N(CH2)2-、R6COOCH2- 或-CH2CON(CH2CH20H)2； R3 是氢、硝基、羟基、氨基、CH3(CH2)nS(O)0-2-、CH3(CH2)n-、CH3(CH2)nO-、R5COO-、RsOOC-、R5HNCOO-、RsNHCO-、RsCONH-、RsNHCONH-、[CH3(CH2)n]2NCO-、CH3(CH2)nCHOHCH20-、(2-quinolinyl)methoxy, oleyloxy, linoleyloxy, R8OOC(CH2)t-O, (R6 0)2 PO(CH2)pO-, (HO) (R60)PO(CH2)pO-, R6[O(CH2)2]qO-, R7(CH2)pO-, 或-O(CH2)p-吡啶鎓+(OH-)； R4 是 CH3(CH2)n- ，CH3(CH2)nO- ，CF3SO2NH- ，RsCOO- ，RsOOC- ，R5HNCOO- ，RsNHCO- ，RsCONH-RsNHCONH- ，[CH3(CH2)n]2NCO- 、R8OOC(CH2)tO-、R6[O(CH2)2]qO- 或 R7(CH2)pO-； R5 是 CH3(CH2)n-、1-金刚烷基或二苯基甲基； R6 是低级烷基 R7 是 1-或 2-萘氧基，1-、2-或 3-吡啶氧基，2,3-或 3,4-二羟基苯基，6,7-二羟基-2-萘基，苯基，苯氧基或取代的苯基或苯氧基，其中取代基选自由低级烷基、低级烷氧基、羟基、硝基、氨基、卤代、R6 S(O)0-2-、羧基、羧基-低级烷基或苯基组成的组； R8 是氢或低级烷基； n 是 0 至 17 的整数； m 是 1 至 3 的整数； t 是 1 至 10 的整数； p 是 2 至 18 的整数，和 q 是 1 至 6 的整数； 以及当 R2 为氢时，其与碱的药学上可接受的盐，是磷脂酶 A2（PLA2）的强效抑制剂，因此可用于治疗炎症性疾病，如银屑病、炎症性肠病、哮喘、过敏、关节炎、皮炎、痛风、肺部疾病、心肌缺血/再灌注，以及创伤引起的炎症，如脊髓损伤。
• Friction-reducing compositions for use in drilling operations
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US10927283B2

  公开（公告）日：2021-02-23

  Friction-reducing compositions useful for reducing Operating Torque in a drilling operation are described. Methods of conducting drilling operations using such friction-reducing compositions and lubricant compositions formed from blends of the friction-reducing composition with an oil-based mud composition are also described.

  本文介绍了在钻井作业中减少操作扭矩的减摩组合物。此外，还介绍了使用此类减摩组合物和由减摩组合物与油基泥浆组合物混合形成的润滑剂组合物进行钻井作业的方法。
• Friction-Reducing Compositions for Use in Drilling Operations
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US20180179432A1

  公开（公告）日：2018-06-28

  Friction-reducing compositions useful for reducing Operating Torque in a drilling operation are described. Methods of conducting drilling operations using such friction-reducing compositions and lubricant compositions formed from blends of the friction-reducing composition with an oil-based mud composition are also described.
• US5324747A
  申请人：——

  公开号：US5324747A

  公开（公告）日：1994-06-28
• US5446189A
  申请人：——

  公开号：US5446189A

  公开（公告）日：1995-08-29

表征谱图