3-chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoic acid | 864297-29-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoic acid
• 英文别名: 3-chloro-4-(5-methyl-3-oxo-morpholin-4-yl)-benzoic acid；3-chloro-4-(3-methyl-5-oxomorpholin-4-yl)benzoic acid
• CAS: 864297-29-0
• 化学式: C₁₂H₁₂ClNO₄
• 分子量: 269.685
• InChiKey: AJJFCFRROPVFLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethylamine 、 3-chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoic acid 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 三乙胺 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 16.0h， 以28%的产率得到3-chloro-N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethyl]-4-(5-methyl-morpholin-3-on-4-yl)-benzamide
  参考文献：
  名称：

  [DE] NEUE CARBONSÄUREAMIDE ALS FAKTOR XA-INHIBITOREN
  [EN] NOVEL CARBOXAMIDES FOR USE AS XA INHIBITORS
  [FR] NOUVEAUX CARBOXAMIDES COMME INHIBITEURS DU FACTEUR XA

  摘要：

  The subject of the present invention is new substituted carboxylic acid amides of the general formula (I), in which A, B, and R1 to R5 are as defined in claim 1, their tautomers, their enantiomers, their diastereomers, their mixtures, and their salts, especially their physiologically acceptable salts with inorganic or organic acids or bases, which have valuable properties. The compounds have an antithrombotic effect and are Factor Xa inhibitors.

  公开号：

  WO2005082895A1
• 作为产物：
  描述：

  3-chloro-4-(5-methyl-3-oxo-morpholin-4-yl)-benzoic acid ethyl ester 、 氢氧化锂 以 四氢呋喃 、 水 为溶剂， 生成 3-chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoic acid
  参考文献：
  名称：

  New carboxylic acid amides, the preparation thereof and their use as medicaments

  摘要：

  本发明涉及一种新的取代羧酸酰胺，其一般式如下：其中A、B和R1至R5如权利要求1所定义，它们的互变异构体、对映异构体、顺反异构体、混合物及其盐，特别是与无机或有机酸或碱的生理上可接受的盐，具有有价值的性质。

  公开号：

  US20050203078A1

文献信息

• New carboxylic acid amides, the preparation thereof and their use as medicaments
  申请人：Priepke Henning

  公开号：US20050203078A1

  公开（公告）日：2005-09-15

  The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R 1 to R 5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

  本发明涉及一般式的新取代羧酸酰胺 其中A、B和R1至R5如权利要求1中定义，其互变异构体、对映体、非对映异构体、它们的混合物及其盐，特别是其与无机或有机酸或碱形成的生理上可接受的盐，具有有价值的性质。
• NEW CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS
  申请人：PRIEPKE Henning

  公开号：US20080146539A1

  公开（公告）日：2008-06-19

  The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R 1 to R 5 are defined as in claim 1 , the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

  本发明涉及一种新的取代羧酸酰胺，其一般式为其中A、B和R1至R5如权利要求1所定义，其互变异构体、对映异构体、顺反异构体、混合物及其与无机或有机酸或碱的生理上可接受的盐，具有有价值的性质。
• CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS
  申请人：PRIEPKE Henning

  公开号：US20130237522A1

  公开（公告）日：2013-09-12

  The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R 1 to R 5 are defined as in claim 1 , the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

  本发明涉及新的取代羧酸酰胺，其一般式为 A、B 和 R1 到 R5 如权利要求1所定义，其互变异构体、对映异构体、顺反异构体、混合物及其与无机或有机酸或碱的生理上可接受的盐，具有有价值的性质。
• US7371743B2
  申请人：——

  公开号：US7371743B2

  公开（公告）日：2008-05-13
• US7947700B2
  申请人：——

  公开号：US7947700B2

  公开（公告）日：2011-05-24