5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid cyclopropylmethyl(2-hydroxyethyl)amide | 1616924-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid cyclopropylmethyl(2-hydroxyethyl)amide
• 英文别名: 5-Benzyloxy-6-hydroxy-2-(1-phenyl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid cyclopropylmethyl-(2-hydroxyethyl)-amide；N-(cyclopropylmethyl)-N-(2-hydroxyethyl)-6-oxo-2-[(1-phenylcyclopentyl)methyl]-5-phenylmethoxy-1H-pyrimidine-4-carboxamide
• CAS: 1616924-73-2
• 化学式: C₃₀H₃₅N₃O₄
• 分子量: 501.626
• InChiKey: FJGPBFRQKQBCOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  91.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  9-benzyloxy-2-cyclopropyl-6-(1-phenylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 、 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid cyclopropylmethyl(2-hydroxyethyl)amide 以The product was obtained as a colourless sticky solid (65 mg, 44.95%)的产率得到9-benzyloxy-2-cyclopropylmethyl-6-(1-phenylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione
  参考文献：
  名称：

  PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

  摘要：

  本发明涉及一种具有一般式(I)的化合物，可选地以药学上可接受的盐、溶剂、多晶形、共药、共晶、前药、互变异构体、外消旋体或对映体或其混合物的形式存在，其在治疗、改善或预防病毒性疾病方面具有用途。此外，还公开了具体的联合治疗方案。

  公开号：

  US20140194431A1
• 作为产物：
  描述：

  5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid cyclopropyl(2-hydroxyethyl)amide 、 5-Benzyloxy-6-hydroxy-2-(1-phenyl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid 5-benzyloxy-6-hydroxy-2-(1-phenyl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-cyclopropylmethyl-amide 以The product was obtained as a light yellow sticky solid (300 mg, 96.93%)的产率得到5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid cyclopropylmethyl(2-hydroxyethyl)amide
  参考文献：
  名称：

  PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

  摘要：

  本发明涉及一种具有一般式(I)的化合物，可选地以药学上可接受的盐、溶剂、多晶形、共药、共晶、前药、互变异构体、外消旋体或对映体或其混合物的形式存在，其在治疗、改善或预防病毒性疾病方面具有用途。此外，还公开了具体的联合治疗方案。

  公开号：

  US20140194431A1

文献信息

• Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
  申请人：Savira pharmaceuticals GmbH

  公开号：US09045486B2

  公开（公告）日：2015-06-02

  The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

  本发明涉及一种具有一般式(I)的化合物，可选地以药学上可接受的盐、溶剂化物、多晶形、共药、共晶体、前药、互变异构体、外消旋体、对映体或其混合物的形式存在，这些化合物对于治疗、改善或预防病毒性疾病是有用的。此外，还披露了特定的组合疗法。
• US9045486B2
  申请人：——

  公开号：US9045486B2

  公开（公告）日：2015-06-02
• [EN] PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE<br/>[FR] DÉRIVÉS PYRIMIDONE ET LEUR UTILISATION DANS LE TRAITEMENT, L'AMÉLIORATION OU LA PRÉVENTION D'UNE MALADIE VIRALE
  申请人：SAVIRA PHARMACEUTICALS GMBH

  公开号：WO2014108406A1

  公开（公告）日：2014-07-17

  The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph,codrug, cocrystal,prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.