2-ethoxy-5-iodopyrimidine | 1083329-43-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-ethoxy-5-iodopyrimidine
• CAS: 1083329-43-4
• 化学式: C₆H₇IN₂O
• 分子量: 250.039
• InChiKey: NWQDWGCCJHJWPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-ethoxy-5-iodopyrimidine 、 苯甲醇 在 copper(l) iodide 、 1,10-菲罗啉 、 cesium bicarbonate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以89%的产率得到2,5-dibenzyloxypyrimidine
  参考文献：
  名称：

  A Simple Cu-Catalyzed Coupling Approach to Substituted 3-Pyridinol and 5-Pyrimidinol Antioxidants

  摘要：

  A convenient approach to 3-pyridinols and 5-pyrimidinols via a two-step Cu-catalyzed benzyloxylation/catalytic hydrogenation sequence is presented. The corresponding 3-pyridinamines and 5-pyrimidinamines can be prepared in an analogous sequence utilizing benzylamine in lieu of benzyl alcohol. The radical-scavenging ability of these derivatives are preliminarily explored and reveal that the increased acidities of the pyridinols and pyrimidinols render them susceptible to more significant kinetic solvent effects when compared to phenols.

  DOI：

  10.1021/jo801501e
• 作为产物：
  描述：

  2-溴-5-碘嘧啶 、 乙醇 在 sodium 作用下， 以 乙醇 为溶剂， 以77%的产率得到2-ethoxy-5-iodopyrimidine
  参考文献：
  名称：

  A Simple Cu-Catalyzed Coupling Approach to Substituted 3-Pyridinol and 5-Pyrimidinol Antioxidants

  摘要：

  A convenient approach to 3-pyridinols and 5-pyrimidinols via a two-step Cu-catalyzed benzyloxylation/catalytic hydrogenation sequence is presented. The corresponding 3-pyridinamines and 5-pyrimidinamines can be prepared in an analogous sequence utilizing benzylamine in lieu of benzyl alcohol. The radical-scavenging ability of these derivatives are preliminarily explored and reveal that the increased acidities of the pyridinols and pyrimidinols render them susceptible to more significant kinetic solvent effects when compared to phenols.

  DOI：

  10.1021/jo801501e

文献信息

• TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF BREAST CANCER
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP3544974A1

  公开（公告）日：2019-10-02
• [EN] TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF BREAST CANCER<br/>[FR] COMPOSÉS D'ALCÈNE TÉTRASUBSTITUÉS ET LEUR UTILISATION POUR LE TRAITEMENT DU CANCER DU SEIN
  申请人：EISAI R&D MAN CO LTD

  公开号：WO2018098305A1

  公开（公告）日：2018-05-31

  Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.