1-ethyl-4-methyl-2-acetamidopyridine | 202831-99-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-ethyl-4-methyl-2-acetamidopyridine
• 英文别名: N-ethyl-N-(4-methylpyridin-2-yl)acetamide
• CAS: 202831-99-0
• 化学式: C₁₀H₁₄N₂O
• 分子量: 178.234
• InChiKey: NLPVJQNBWGOACB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [TpRu(COD)Cl] 、 1-ethyl-4-methyl-2-acetamidopyridine 以 N,N-二甲基甲酰胺 为溶剂， 以89%的产率得到[Ru(HB(C3H3N2)3)(1-ethyl-2-acetamido-4-methylpyridyl)Cl]
  参考文献：
  名称：

  Ruthenium Tripyrazolylborate Complexes. 9.¹ Formation and Characterization of Amidocarbene Complexes

  摘要：

  The complexes of the RuTpCl fragment with the mixed bidentate ligands 2-acetamidopyridine (Haapy), 2-acetamido-4-methylpyridine (4-Me-Haapy), and 1-ethyl-2-acetamido-4methylpyridine (N-Et-4-Me-Haapy) are synthesized and their reactions with acetylenes are described. RuTp(Haapy)Cl (2a) reacts in an unexpected manner with HC=CR (R = Ph, n-Bu) to give cyclic amido carbene complexes RuTp(=CCH2R-aapy)Cl (3, 4). In the case of R = C(Me)(Ph)OH and C6H11 the vinylcarbene complexes RuTp(=CCH=C(Me)Ph-aapy)Cl (5) and RuTp(=CCH=C6H10-aapy)Cl (6) are obtained, and with R = COOEt and COOMe the olefin complexes RuTp(aapy-CH=CHCOOEt)Cl (7) and RuTp(aapy-CH=CHCOOMe)Cl (8) are formed. Solvates of complexes 2b and 3 are characterized by X-ray crystallography.

  DOI：

  10.1021/om970951u