[(4R,4aR,7S,7aR,12bS)-9-acetyloxy-3-methyl-1,2,3,4,4a,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-7-yl] acetate;chloride;hydrate

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: [(4R,4aR,7S,7aR,12bS)-9-acetyloxy-3-methyl-1,2,3,4,4a,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-7-yl] acetate;chloride;hydrate
• 化学式: C21H26ClNO6
• 分子量: 423.9
• InChiKey: RXHOCRVNZZBATK-NRXBBNKASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.59
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  66.1
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Method and apparatus for detecting, locating, and analyzing chemical compounds using subatomic particle activation
  申请人：——

  公开号：US20030165212A1

  公开（公告）日：2003-09-04

  An apparatus and method for detecting, locating, and analyzing chemical compounds located within a test subject using subatomic particle activation. In a first embodiment, an excitation source excites a target to simultaneously produce beams each consisting of certain subatomic species, for example fast neutrons and alpha particles. The test subject (and chemical compounds contained therein) is irradiated by the fast neutrons, thereby stimulating the emission of prompt gamma rays. Gamma and alpha detectors are positioned relative to the test subject and target(s) so as to detect the emitted prompt gamma rays and alpha particles in substantial coincidence, and the known physical relationship between the beams is used to spatially locate the activated chemical compound. Energy spectra derived from the gamma detectors are filtered to eliminate all non-relevant spectral artifacts, thereby 1) permitting the creation of a plurality of parallel coincidence channels; 2) reducing the subsequent signal processing required; and 3) increasing the overall accuracy and efficiency of the chemical compound identification and analysis processes. In a second embodiment, thermal neutron-induced gamma emissions are detected and analyzed in conjunction with the fast neutron-induced gammas to provide a warning signal of the possible presence of certain types of contraband. A multi-beam/multi-target embodiment is also disclosed for more accurate spatial location. A method for calibrating and evaluating the efficacy of the system under varying test parameters is further disclosed.

  一种利用亚原子粒子活化技术检测、定位和分析位于测试对象体内的化合物的仪器和方法。在第一个实施方案中，激发源激发目标，同时产生由特定亚原子种类（例如快中子和阿尔法粒子）组成的光束。测试对象（及其所含化合物）受到快中子的辐照，从而激发瞬时伽马射线的发射。伽马射线和α粒子探测器相对于测试对象和目标物进行定位，以便检测到发射的瞬时伽马射线和α粒子是否完全重合，并利用光束之间的已知物理关系对活化的化合物进行空间定位。从伽马探测器得到的能谱经过过滤，以消除所有无关的光谱伪影，从而：1）允许创建多个并行的重合通道；2）减少所需的后续信号处理；3）提高化合物识别和分析过程的整体准确性和效率。在第二个实施方案中，热中子诱发伽马辐射与快中子诱发伽马辐射一起检测和分析，以提供可能存在某些类型违禁品的警告信号。还披露了一种多波束/多目标实施方案，用于更精确的空间定位。还披露了在不同测试参数下校准和评估系统功效的方法。
• Method and apparatus for neutron microscopy with stoichiometric imaging
  申请人：——

  公开号：US20030165213A1

  公开（公告）日：2003-09-04

  A system provides non-invasive stoichiometric detection and imaging of chemical elements and compounds in a material to be analyzed. The system includes a particle generator which generates first and second particles at a target position a first distance from the material. The system further comprises a photon detector capable of detecting photons resulting from irradiation of the material by the first particles and generating a plurality of first electrical signals. The system further comprises a particle detector array for detecting the second partices at a second distance, larger than the first distance, from the target position and generating a plurality of second electrical signals. The system further comprises an analyzer comprising a processor that produces a plurality of filtered electrical signals. The analyzer further comprises a plurality of electronic coincidence circuits which detect coincidences occurring between the plurality of filtered electrical signals and the plurality of second electrical signals.

  一种系统可对待分析材料中的化学元素和化合物进行非侵入式化学计量检测和成像。该系统包括一个粒子发生器，可在距离材料第一距离的目标位置产生第一和第二粒子。该系统还包括一个光子探测器，能够检测第一粒子照射材料产生的光子，并产生多个第一电信号。该系统还包括一个粒子探测器阵列，用于在距离目标位置大于第一距离的第二距离处检测第二粒子，并产生多个第二电信号。系统还包括一个分析仪，该分析仪包含一个处理器，可产生多个滤波电信号。分析仪还包括多个电子重合电路，用于检测多个滤波电信号和多个第二电信号之间发生的重合。
• Binocular method and apparatus for stoichiometric analysis and imaging using subatomic particle activation
  申请人：Maglich C. Bogdan

  公开号：US20050195931A1

  公开（公告）日：2005-09-08

  An apparatus and method for detecting, locating, and analyzing chemical compounds located within a test subject using subatomic particle activation. In a first embodiment, an excitation source excites a target to simultaneously produce beams each consisting of certain subatomic species, for example fast neutrons and alpha particles. The test subject (and chemical compounds contained therein) is irradiated by the fast neutrons, thereby stimulating the emission of prompt gamma rays. Gamma and alpha detectors are positioned relative to the test subject and target(s) so as to detect the emitted prompt gamma rays and alpha particles in substantial coincidence, and the known physical relationship between the beams is used to spatially locate the activated chemical compound. Energy spectra derived from the gamma detectors are filtered to eliminate all non-relevant spectral artifacts, thereby 1) permitting the creation of a plurality of parallel coincidence channels; 2) reducing the subsequent signal processing required; and 3) increasing the overall accuracy and efficiency of the chemical compound identification and analysis processes. In a second embodiment, thermal neutron-induced gamma emissions are detected and analyzed in conjunction with the fast neutron-induced gammas to provide a warning signal of the possible presence of certain types of contraband. A multi-beam/multi-target embodiment is also disclosed for more accurate spatial location. A method for calibrating and evaluating the efficacy of the system under varying test parameters is further disclosed.

  一种利用亚原子粒子活化技术检测、定位和分析位于测试对象体内的化合物的仪器和方法。在第一个实施方案中，激发源激发目标，同时产生由特定亚原子种类（例如快中子和阿尔法粒子）组成的光束。测试对象（及其所含化合物）受到快中子的辐照，从而激发瞬时伽马射线的发射。伽马射线和α粒子探测器相对于测试对象和目标物进行定位，以便检测到发射的瞬时伽马射线和α粒子是否完全重合，并利用光束之间的已知物理关系对活化的化合物进行空间定位。从伽马探测器得到的能谱经过过滤，以消除所有无关的光谱伪影，从而：1）允许创建多个并行的重合通道；2）减少所需的后续信号处理；3）提高化合物识别和分析过程的整体准确性和效率。在第二个实施方案中，热中子诱发伽马辐射与快中子诱发伽马辐射一起检测和分析，以提供可能存在某些类型违禁品的警告信号。还披露了一种多波束/多目标实施方案，用于更精确的空间定位。还披露了在不同测试参数下校准和评估系统功效的方法。
• Hybrid stoichiometric analysis and imaging using non-thermal and thermal neutrons
  申请人：Maglich C. Bogdan

  公开号：US20060227920A1

  公开（公告）日：2006-10-12

  An apparatus and method for analyzing and imaging chemical compounds within a test subject uses subatomic particle activation. The test subject (and chemical compounds contained therein) is irradiated by non-thermal neutrons, thereby generating thermal neutrons within the test subject and stimulating the emission of gamma rays. Gamma ray detectors detect the emitted gamma rays and energy signals derived from the gamma ray detectors are filtered to eliminate non-relevant spectral artifacts.

  一种利用亚原子粒子活化对测试对象体内的化合物进行分析和成像的仪器和方法。测试对象（及其所含的化合物）受到非热中子的照射，从而在测试对象内部产生热中子并激发伽马射线的发射。伽马射线探测器探测发射的伽马射线，并对伽马射线探测器产生的能量信号进行过滤，以消除不相关的光谱伪影。
• METHOD AND APPARATUS FOR NEUTRON MICROSCOPY WITH STOICHIOMETRIC IMAGING
  申请人：Hienergy Microdevices, Inc.

  公开号：EP1448980A2

  公开（公告）日：2004-08-25