N-(2-((2-((1-(2,2-difluoroethyl)-3-methyl-1H-pyrazol-4-yl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)methanesulfonamide | 1258944-41-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(2-((2-((1-(2,2-difluoroethyl)-3-methyl-1H-pyrazol-4-yl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)methanesulfonamide
• 英文别名: N-[2-[[2-[[1-(2,2-difluoroethyl)-3-methylpyrazol-4-yl]amino]-5-fluoropyrimidin-4-yl]amino]phenyl]methanesulfonamide
• CAS: 1258944-41-0
• 化学式: C₁₇H₁₈F₃N₇O₂S
• 分子量: 441.437
• InChiKey: OTBVGFRTHJKTOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• [EN] HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS<br/>[FR] HÉTÉROCYCLYLAMINOPYRIMIDINES SERVANT D'INHIBITEURS DE KINASES
  申请人：CELLZOME LTD

  公开号：WO2010146133A1

  公开（公告）日：2010-12-23

  The invention relates to compounds of formula (I), wherein R1 to R6 and T0 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of ZAP-70, Syk or JAK3 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

  本发明涉及公式(I)的化合物，其中R1至R6和T0的含义如所述和权利要求中所述。所述化合物可用作ZAP-70、Syk或JAK3的抑制剂，用于治疗或预防免疫、炎症、自身免疫、过敏性疾病和免疫介导疾病。本发明还涉及包括所述化合物的制药组合物，以及作为药物的用途和制备该类化合物的方法。
• HETEROCYCLYLAMINOPYRIMIDINES AS KINASE INHIBITORS
  申请人：Sunose Mihiro

  公开号：US20120172384A1

  公开（公告）日：2012-07-05

  The invention relates to compounds of formula (I) wherein R 1 to R 6 and T 0 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of ZAP-70, Syk or JAK3 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

  本发明涉及式（I）化合物，其中R1至R6和T0具有所述描述和权利要求中所引用的含义。所述化合物可用作ZAP-70、Syk或JAK3的抑制剂，用于治疗或预防免疫、炎症、自身免疫、过敏性疾病和免疫介导性疾病。本发明还涉及包括所述化合物的制药组合物，以及作为药物的使用和制备这些化合物。