4-bromo-N-(1-methylpiperidin-4-yl)benzenesulfonamide | 888195-78-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-bromo-N-(1-methylpiperidin-4-yl)benzenesulfonamide
• CAS: 888195-78-6
• 化学式: C₁₂H₁₇BrN₂O₂S
• 分子量: 333.249
• InChiKey: XIBVAWGPYWOSHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  、 4-bromo-N-(1-methylpiperidin-4-yl)benzenesulfonamide 在 tris-(dibenzylideneacetone)dipalladium(0) 、 lithium tert-butoxide 、 2-二环己基磷-2,4,6-三异丙基联苯 作用下， 以 1,4-二氧六环 为溶剂， 生成 4-(1-(10H-phenothiazine-2-yl)vinyl)-N-(1-methylpiperidin-4-yl)benzenesulfonamide
  参考文献：
  名称：

  Design and synthesis of sulfonamide phenothiazine derivatives as novel ferroptosis inhibitors and their therapeutic effects in spinal cord injury

  摘要：

  DOI：

  10.1016/j.bioorg.2024.107458
• 作为产物：
  描述：

  4-溴苯磺酰氯 、 4-氨基-1-甲基哌啶 在 4-bromo-N-(1-methylpiperidin-4-yl)benzenesulfonamide 作用下， 以to give the title compound (245 mg, 94%)的产率得到4-bromo-N-(1-methylpiperidin-4-yl)benzenesulfonamide
  参考文献：
  名称：

  Pyrimidine Derivatives and Their Use in Therapy as well as the Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease

  摘要：

  该专利涉及式I的化合物，其中R1，R2，R3，R4，R5，R6，R7，R8和R9如规范中所定义，作为基础物质或药物可接受的盐，溶剂或其盐的溶剂，以及制备它们的方法，其中使用了新的中间体，含有所述化合物的制药配方以及在治疗中使用所述化合物的用途。

  公开号：

  US20090105252A1
• 作为试剂：
  描述：

  4-溴苯磺酰氯 、 4-氨基-1-甲基哌啶 在 4-bromo-N-(1-methylpiperidin-4-yl)benzenesulfonamide 作用下， 以to give the title compound (245 mg, 94%)的产率得到4-bromo-N-(1-methylpiperidin-4-yl)benzenesulfonamide
  参考文献：
  名称：

  Pyrimidine Derivatives and Their Use in Therapy as well as the Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease

  摘要：

  该专利涉及式I的化合物，其中R1，R2，R3，R4，R5，R6，R7，R8和R9如规范中所定义，作为基础物质或药物可接受的盐，溶剂或其盐的溶剂，以及制备它们的方法，其中使用了新的中间体，含有所述化合物的制药配方以及在治疗中使用所述化合物的用途。

  公开号：

  US20090105252A1

文献信息

• 10H-PHENOTHIAZINE FERROPTOSIS INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
  申请人：Chengdu Henghao Investment Co. Limited

  公开号：EP3786156A1

  公开（公告）日：2021-03-03

  This disclosure are related to 10H-phenothiazine derivatives capable of inhibiting ferroptosis, or pharmaceutically acceptable salts thereof, or crystal forms thereof, or solvates thereof as shown in formula (I), and a preparation method therefor and applications thereof. The derivatives take a good inhibitory effect on ferroptosis, show a good therapeutic effect on a rat model of focal cerebral ischemia and thus can be used as a main active ingredient in the preparation of ferroptosis inhibitors. The compounds and the inhibitors prepared by the compounds have good medicinal potential and are expected to be used as drug candidates for the treatment of stroke.

  本公开涉及如式(I)所示的能够抑制铁卟啉中毒的10H-吩噻嗪衍生物，或其药学上可接受的盐，或其晶体形式，或其溶解物，及其制备方法和应用。这些衍生物对铁凋亡有很好的抑制作用，对局灶性脑缺血大鼠模型有很好的治疗效果，因此可作为制备铁凋亡抑制剂的主要活性成分。该化合物及其制备的抑制剂具有良好的药用潜力，有望作为治疗中风的候选药物。
• NEW PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY AS WELL AS THE USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER'S DISEASE
  申请人：AstraZeneca AB

  公开号：EP1945628A1

  公开（公告）日：2008-07-23
• 10H-phenothiazine ferroptosis inhibitor as well as the preparative method and the use thereof
  申请人：CHENGDU HENGHAO INVESTMENT CO. LIMITED

  公开号：US20210040079A1

  公开（公告）日：2021-02-11

  10H-phenothiazine derivatives capable of inhibiting ferroptosis has structural formula (I). The derivatives, pharmaceutically acceptable salts thereof, crystal forms thereof, or solvates thereof exhibit inhibitory effect on ferroptosis, and therapeutic effect on a rat model of focal cerebral ischemia and thus can be used as a main active ingredient in the preparation of ferroptosis inhibitors. The compounds and the inhibitors prepared by the compounds have good medicinal potential and are expected to be used as drug candidates for the treatment of stroke.
• [EN] NEW PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY AS WELL AS THE USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] NOUVEAUX DERIVES DE PYRIMIDINE ET LEUR UTILISATION EN THERAPIE ET POUR LA PRODUCTION D'UN MEDICAMENT POUR LA PREVENTION ET/OU LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：ASTRAZENECA AB

  公开号：WO2007040440A1

  公开（公告）日：2007-04-12

  [EN] The present invention relates to use of compounds of formula (I) as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, as pharmaceutical ingredients for treatment of dementia, Alzheimer's Disease, Parkinson's Disease, Frontotemporal dementia Parkinson's Type, Parkinson dementia complex of Guam, HIV dementia, diseases with associated neurofibrillar tangle pathologies and/or dementia pugilistica .
  [FR] L'invention concerne l'utilisation de composés de formule (I) en tant que base libre ou un sel, solvate ou solvate d'un sel acceptable sur le plan pharmaceutique de ceux-ci. L'invention concerne également un procédé de préparation desdits composés et des nouveaux intermédiaires utilisés dans ce procédé. Lesdits composés sont utilisés en tant qu'ingrédients pharmaceutiques pour le traitement des maladies suivantes : démences, maladie d'Alzheimer, maladie de Parkinson, démences frontotemporales de type Parkinson, Parkinson démence île de Guam, démence associée au VIH, maladies à enchevêtrement neurofibrillaire associé et/ou démence pugilistique.