1-(isobutylamino)-3-methyl-2,5-dihydro-1H-phosphole-1-oxide | 1428266-05-0

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 英文名称: 1-(isobutylamino)-3-methyl-2,5-dihydro-1H-phosphole-1-oxide
• 英文别名: 1-isobutylamino-3-methyl-3-phospholene 1-oxide；3-methyl-N-(2-methylpropyl)-1-oxo-2,5-dihydro-1lambda5-phosphol-1-amine；3-methyl-N-(2-methylpropyl)-1-oxo-2,5-dihydro-1λ5-phosphol-1-amine
• CAS: 1428266-05-0
• 化学式: C₉H₁₈NOP
• 分子量: 187.222
• InChiKey: ZGIWDWGKAZQGMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-hydroxy-3-methyl-3-phospholene 1-oxide 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 26.0h， 生成 1-(isobutylamino)-3-methyl-2,5-dihydro-1H-phosphole-1-oxide
  参考文献：
  名称：

  Synthesis of 1-Amino-2,5-dihydro-1H-phosphole 1-Oxides and Their N-Phosphinoyl Derivatives, Bis(2,5-dihydro-1H-phosphol-1-yl)amine P,P′-Dioxides

  摘要：

  Depending on the molar ratio of the reactants and on the order of mixing, the reactions of a series of primary amines with 1-chloro-2,5-dihydro-1H-phosphole 1-oxides prepared in situ from the corresponding hydroxy-dihydrophosphole oxides afforded 1-amino-2,5-dihydro-1H-phosphole 1-oxides, or their N-phosphinoyl derivatives, bis(2,5-dihydro-1H-phosphol-1-yl)amine P,P'-dioxides. The latter family of P-heterocycles could also be synthesized by the reaction of 1-amino-2,5-dihydro-1H-phosphole oxides with chloro-dihydrophosphole oxides.

  DOI：

  10.1055/s-0032-1316830

文献信息

• T3P®-assisted esterification and amidation of phosphinic acids
  作者：Erzsébet Jablonkai、Réka Henyecz、Mátyás Milen、János Kóti、György Keglevich

  DOI：10.1016/j.tet.2014.09.021

  日期：2014.11

  A few phosphinic acids, such as phenylphosphinic acids, 1-hydroxy-3-phospholene 1-oxides and 1-hydroxyphospholane oxides are esterified with simple alcohols in the presence of propylphosphonic anhydride (T3P®). If 1.1 equiv of the T3P® reagent is used, the esterifications are fast and efficient at 25° C. In the case of more reactive models it was enough to apply 0.66 equiv of T3P® at 85° C under microwave

  少数次膦酸，苯基次作为酸，1-羟基-3-环磷-1-氧化物和1- hydroxyphospholane氧化物，例如酯化，在丙基膦酸酐（T3P的存在简单的醇®）。如果T3P的1.1当量®使用试剂时，酯化是快速和有效的在25℃下在多种反应性模型它足以适用0.66当量T3P的情况下®在85℃在微波条件下。1-羟基-3-甲基-3-氧化膦的酰胺化也可以在类似条件下完成。