(2Z,5Z)-N-[5-({2-[(3-fluoro-4-hydroxyphenyl)azamethylene]-4-oxo-1,3-thiazolidin-5-ylidene}methyl)-1,3-thiazol-2-yl]acetamide | 1253209-80-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2Z,5Z)-N-[5-({2-[(3-fluoro-4-hydroxyphenyl)azamethylene]-4-oxo-1,3-thiazolidin-5-ylidene}methyl)-1,3-thiazol-2-yl]acetamide
• 英文别名: N-[5-[(Z)-[2-(3-fluoro-4-hydroxyphenyl)imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl]-1,3-thiazol-2-yl]acetamide
• CAS: 1253209-80-1
• 化学式: C₁₅H₁₁FN₄O₃S₂
• 分子量: 378.408
• InChiKey: WTNBOECCPJTMEO-XGICHPGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  157
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• THIAZOLIDINONE DERIVATIVE
  申请人：Irie Takayuki

  公开号：US20110190299A1

  公开（公告）日：2011-08-04

  An object of the present invention is to provide thiazolidinone derivatives. More specifically, an object of the present invention is to provide novel compounds having a CDC7 inhibitory action. The present invention provides thiazolidinone derivatives represented by the formula (I) The compounds of the present invention inhibit the CDC7 protein kinase activity, and suppress cell proliferation.

  本发明的目的是提供噻唑烷酮衍生物。更具体地，本发明的目的是提供具有CDC7抑制作用的新化合物。本发明提供由式(I)表示的噻唑烷酮衍生物。本发明的化合物抑制CDC7蛋白激酶活性，并抑制细胞增殖。
• N-alkoxy-4,4-dioxy-polyalkyl-piperidine compounds, with glycidyl or alkylcarbonyl groups as functional initiators for controlled radical polymerization
  申请人：——

  公开号：US20040049043A1

  公开（公告）日：2004-03-11

  The present invention relates to selected glycidyl or carbonyl functional N-alkoxy-4,4-dioxy-polaylkyl-piperidine compounds forming an open chain or cyclic ketal structure, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) a glycidyl or carbonyl functional N-alkoxy-4,4-dioxy-polyalkyl-piperidine nitroxide initiator compound. Further aspects of the present invention are a process for polymerizing ethylenically unsaturated monomers and the use of glycidyl or carbonyl functional N-alkoxy-4,4-dioxy-polyalkyl-piperidine nitroxide initiators for radical polymerization.

  本发明涉及选择的含有环氧基或羰基基团的N-烷氧基-4,4-二氧-聚烯烃-哌啶化合物，形成开链或环状的酮缩结构，一种聚合物组合物，包括a)至少一种乙烯基不饱和单体和b)含有环氧基或羰基基团的N-烷氧基-4,4-二氧-聚烯烃-哌啶自由基引发剂化合物。本发明的进一步方面包括聚合乙烯基不饱和单体的方法以及使用含有环氧基或羰基基团的N-烷氧基-4,4-二氧-聚烯烃-哌啶自由基引发剂进行自由基聚合的方法。
• [EN] CATIONIC ALKOXYAMINES AND THEIR USE IN PRODUCING NANO PARTICLES FROM NATURAL OR SYNTHETIC CLAYS<br/>[FR] ALKOXYAMINES CATIONIQUES ET UTILISATION DANS LA PRODUCTION DE NANOPARTICULES A PARTIR D'ARGILES NATURELLES OU SYNTHETIQUES
  申请人：CIBA SC HOLDING AG

  公开号：WO2004000809A1

  公开（公告）日：2003-12-31

  The instant invention relates to cationic alkoxyamines, which are useful as polymerization initiators/regulators in a controlled stable free radical polymerization process to produce intercalated and/or exfoliated nanoparticles from natural or synthetic clays. The invention also relates to improved nanocomposites produced by this process and to the use of these nanocomposite compositions as, for example, coatings, sealants, caulks, adhesives and as plastic additives.

  该瞬时发明涉及阳离子烷氧胺，其在受控稳定自由基聚合过程中作为聚合引发剂/调节剂，用于从天然或合成黏土中产生层间和/或剥离的纳米粒子。该发明还涉及通过这一过程生产的改进纳米复合材料，以及将这些纳米复合物组合物用作例如涂料、密封剂、填缝剂、粘合剂和塑料添加剂。
• Cationic alkoxyamines and their use in producing nano particles from natural or synthetic clays
  申请人：Muhlebach Andreas

  公开号：US20050215691A1

  公开（公告）日：2005-09-29

  The instant invention relates to cationic alkoxyamines, which are useful as polymerization initiators/regulators in a controlled stable free radical polymerization process to produce intercalated and/or exfoliated nanoparticles from natural or synthetic clays. The invention also relates to improved nanocomposites produced by this process and to the use of these nanocomposite compositions as, for example, coatings, sealants, caulks, adhesives and as plastic additives.

  本发明涉及阳离子烷氧胺，它们在受控稳定自由基聚合过程中作为聚合引发剂/调节剂，用于从天然或合成黏土中生产插层和/或剥离纳米颗粒。本发明还涉及通过该过程生产的改进纳米复合材料以及将这些纳米复合材料组成物用作涂料、密封剂、填缝剂、粘合剂和塑料添加剂等的用途。
• 4-Imino-n-alkoxy or oxy-polyalkyl-piperidine compounds and their use as polymerization regulators
  申请人：——

  公开号：US20040176553A1

  公开（公告）日：2004-09-09

  The present invention relates to selected 4-imino-N-alkoxy-polyalkyl-peperidine compounds preparation, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) a 4-imino-N-alkoxy-polyalkyl-piperidine compound. Further aspects of the present invention are a process for polymerizing ethylenically unsaturated monomers, and the use of 4-imino-N-alkoxy-polyalkyl-piperidine compounds for controlled polymerization. The intermediate N-oxyl derivatives, a composition of the N-oxyl derivatives with ethylenically unsaturated monomers and a free radical initiator, as well as a process for polymerization are also subjects of the present invention. 1

  本发明涉及选择的4-亚氨基-N-烷氧基-聚烷基-哌啶化合物的制备，包括a）至少一种乙烯基不饱和单体和b）4-亚氨基-N-烷氧基-聚烷基-哌啶化合物的可聚合组合物。本发明的其他方面包括聚合乙烯基不饱和单体的过程，以及使用4-亚氨基-N-烷氧基-聚烷基-哌啶化合物进行控制聚合的方法。中间体N-氧代衍生物，N-氧代衍生物与乙烯基不饱和单体和自由基引发剂的组合物，以及聚合的过程也是本发明的主题。