25,26,27,28-tetrakis(succinimidoxycarbonylmethoxy)-p-tert-butylcalix[4]arene | 182487-15-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 25,26,27,28-tetrakis(succinimidoxycarbonylmethoxy)-p-tert-butylcalix[4]arene
• 英文别名: (2,5-Dioxopyrrolidin-1-yl) 2-[[5,11,17,23-tetratert-butyl-26,27,28-tris[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]-25-pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaenyl]oxy]acetate
• CAS: 182487-15-6
• 化学式: C₆₈H₇₆N₄O₂₀
• 分子量: 1269.37
• InChiKey: HHOJQGGLAZJKCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  92
• 可旋转键数：
  24
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  292
• 氢给体数：
  0
• 氢受体数：
  20

反应信息

• 作为反应物：
  描述：

  25,26,27,28-tetrakis(succinimidoxycarbonylmethoxy)-p-tert-butylcalix[4]arene 在 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 C₆₄H₈₄N₄O₁₆
  参考文献：
  名称：

  水溶性手性N-酰基杯（4）芳烃氨基酸衍生物的合成

  摘要：

  合成了一种新型的水溶性手性N-酰基杯（4）芳烃氨基酸衍生物。根据NMR光谱，手性杯（4）芳烃为“圆锥”构型。我们报告使用该手性杯芳烃衍生物作为毛细管电泳中的流动相添加剂的初步结果。

  DOI：

  10.1016/0040-4039(96)01240-3
• 作为产物：
  描述：

  4-叔丁基杯[4]芳烃-四乙酸乙酯 在 sodium hydroxide 、 N,N'-二环己基碳二亚胺 作用下， 以 乙醇 、 水 、 乙酸乙酯 为溶剂， 反应 96.0h， 生成 25,26,27,28-tetrakis(succinimidoxycarbonylmethoxy)-p-tert-butylcalix[4]arene
  参考文献：
  名称：

  Molecular scaffolds for di-metallic complexation: the synthesis, characterisation and complexation properties of tetrakis-terpyridinyl-calix[4]arene

  摘要：

  The ligand tetrakis-terpyridinyl-calix[4]arene is used as a rigid scaffold and pre-organiser of supramolecular assemblies by complexation of the Ni(II), Cu(II) and Co(II) cations. The ligand synthesis was carried out using peptide synthesis conditions by coupling 4'-(2-aminoethoxy)-2,2'/6',2"-terpyridine to the tetra-succinimidoyl activated ester of p-tert-butylcalix[4]arene. The studies on complexation by UV show the existence of M2L-type complexes. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01386-2

文献信息

• Low-generation dendrimers with a calixarene core and based on a chiral <i>C</i>₂-symmetric pyrrolidine as iminosugar mimics
  作者：Marco Marradi、Stefano Cicchi、Francesco Sansone、Alessandro Casnati、Andrea Goti

  DOI：10.3762/bjoc.8.107

  日期：——

  The preparation of low-generation dendrimers based on a simple calix[4]arene scaffold by insertion of the iminosugar-analogue C₂-symmetric 3,4-dihydroxypyrrolidine is described. This methodology allows a rapid incorporation of a considerable number of iminosugar-like moieties in a reduced volume and in a well-defined geometry. The inclusion of alkali-metal ions (sodium and potassium) in the polar cavity defined by the acetamide moieties at the lower rim of the calixarene was demonstrated, which allows also the rigidification of the dendrimer structure and the iminosugar presentation in the clusters. The combination of the supramolecular properties of calixarenes with the advantage of a dendrimeric presentation of repetitive units opens up the possibility of generating well-defined multivalent and multifaceted systems with more complex and/or biologically relevant iminosugars.

  基于简单的杯[4]芳烃支架制备低代数树状聚合物，通过插入类似亚胺糖的C2对称3,4-二羟基吡咯烷来实现。这种方法允许在较小的体积和明确定义的几何形状中快速引入大量类似亚胺糖的基团。在杯芳烃底部的乙酰胺基团定义的极性腔中展示了碱金属离子（钠和钾）的包容，这也使得树状聚合物结构变得更加刚性，并在团簇中呈现亚胺糖。将杯芳烃的超分子特性与树状聚合物呈现重复单元的优势相结合，为生成具有更复杂和/或生物相关亚胺糖的明确定义多价和多方面系统打开了可能性。
• Synthesis of calix[4]arene podands bearing two and four histidine or glycine groups at the lower rim. Complexation properties towards cobalt(II) chloride
  作者：Yann Molard、Cécile Bureau、Hélène Parrot-Lopez、Roger Lamartine、Jean-Bernard Regnouf-de-Vains

  DOI：10.1016/s0040-4039(99)01243-5

  日期：1999.8

  Four calix[4]arene podands displaying two or four glycine or histidine arms at the lower rim have been synthesised and fully characterised. Their coordinating behaviour towards cobalt(II) chloride has been investigated.

  合成并充分表征了四个在下部边缘显示两个或四个甘氨酸或组氨酸臂的杯[4]芳烃荚带。研究了它们对氯化钴（II）的配位行为。
• Novel synthetic receptors based on para-amino-pyridine ligands coupled to p-tert-butylcalix[4]arene via amino-acid spacers
  作者：Yann Molard、Hélène Parrot-Lopez

  DOI：10.1016/s0040-4039(01)00849-8

  日期：2001.7

  The synthesis of a series novel receptors based on p-tert-butylcalix[4]arene tetra-substituted at the lower rim by pyridinyl derivatives of the amino acids, glycine, alanine and lysine is described. (C) 2001 Elsevier Science Ltd. All rights reserved.