4-cyclohexyl-2-(methylthio)pyrimidine-5-carboxylic acid | 1191097-28-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-cyclohexyl-2-(methylthio)pyrimidine-5-carboxylic acid
• 英文别名: 4-Cyclohexyl-2-methylsulfanylpyrimidine-5-carboxylic acid
• CAS: 1191097-28-5
• 化学式: C₁₂H₁₆N₂O₂S
• 分子量: 252.337
• InChiKey: WOAYFIJSACEGAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  88.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281
  申请人：GILL Adrian Liam

  公开号：US20090264401A1

  公开（公告）日：2009-10-22

  A compound of formula (I): and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.

  一种具有化学式（I）的化合物： 及其药用盐，其中变量基团在其中定义；还描述了它们在抑制11βHSD1中的应用，制备它们的方法以及包含它们的药物组合物。
• 2, 4-disubstituted pyrimidine-5-carboxamide derivatives as KCNQ potassium channel modulators
  申请人：——

  公开号：US20020183335A1

  公开（公告）日：2002-12-05

  There is provided a method of treatment for disorders responsive to the modulation of KCNQ potassium channels by administering to a mammal in need thereof a therapeutically effective amount of a 2,4-disubstituted pyrimidine-5-carboxamide derivative of the Formula I 1 wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined below. The present invention also provides pharmaceutical compositions comprising openers or activators of the KCNQ potassium channels and especially to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine.

  提供了一种治疗对KCNQ钾通道调节敏感的疾病的方法，包括向需要治疗的哺乳动物中投与治疗有效量的公式I1的2,4-二取代嘧啶-5-羧酰胺衍生物，其中R1、R2、R3、R4和R5如下定义。本发明还提供了包含KCNQ钾通道开放剂或激活剂的制药组合物，特别是针对对KCNQ钾通道开放活性敏感的疾病的治疗方法，如偏头痛。
• 2,4-DISUBSTITUTED PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP1361879A1

  公开（公告）日：2003-11-19
• [EN] 2,4-DISUBSTITUTED PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS<br/>[FR] DERIVES DE 2,4-DISUBSTITUE PYRIMIDINE-5-CARBOXAMIDE EN TANT QUE MODULATEUR DES CANAUX POTASSIUM KCNQ
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2002066036A1

  公开（公告）日：2002-08-29

  There is provided a method of treatment for disorders responsive to the modulation of KCNQ potassium channels by administering to a mammal in need thereof a therapeutically effective amount of a 2,4-disubstituted pyrimidine-5-carboxamide derivative of Formula (I) wherein R?1, R2, R3, R4 and R5¿ are as defined in the description. The present invention also provides pharmaceutical compositions comprising openers or activators of the KCNQ potassium channels and especially to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine.
• [EN] SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281<br/>[FR] PYRIMIDINE-5-CARBOXAMIDES SUBSTITUÉS
  申请人：ASTRAZENECA AB

  公开号：WO2009130496A1

  公开（公告）日：2009-10-29

  A compound of formula (I) and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.