(4S,5R,6R)-4,5-dihydroxy-2-(4-methoxybenzyl)-6-phenyl[1,2]oxazinan-3-one | 1004756-98-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (4S,5R,6R)-4,5-dihydroxy-2-(4-methoxybenzyl)-6-phenyl[1,2]oxazinan-3-one
• CAS: 1004756-98-2
• 化学式: C₁₈H₁₉NO₅
• 分子量: 329.353
• InChiKey: XHYAEROFOIBAQO-IXDOHACOSA-N

反应信息

• 作为产物：
  描述：

  N-((S)-1-phenylallyloxy)-N-(4-methoxybenzyl)acrylamide 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) potassium bromate 、 四氧化锇 作用下， 以 苯 、 四氢呋喃 、 水 为溶剂， 反应 20.0h， 生成 (4S,5R,6R)-4,5-dihydroxy-2-(4-methoxybenzyl)-6-phenyl[1,2]oxazinan-3-one 、 (4R,5S,6R)-4,5-dihydroxy-2-(4-methoxybenzyl)-6-phenyl[1,2]oxazinan-3-one 、 (4S,5R,6S)-4,5-dihydroxy-2-(4-methoxybenzyl)-6-phenyl[1,2]oxazinan-3-one 、 (4R,5S,6S)-4,5-dihydroxy-2-(4-methoxybenzyl)-6-phenyl[1,2]oxazinan-3-one
  参考文献：
  名称：

  Enantioselective synthesis of [1,2]-oxazinone scaffolds and [1,2]-oxazine core structures of FR900482

  摘要：

  Several chiral unsaturated [1,2]-oxazinone heterocycles have been synthesized by iridium-catalyzed allylic substitution and ring-closing metathesis (RCM) reaction in high yields with excellent enantiomeric excesses. In addition, the synthesis of [1,2]-oxazine core structures of FR900482 was achieved via iridiurn-catalyzed allylic substitution, followed by RCM and Heck reactions, respectively. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.07.071