dizinc;2-[4-[2-[2-[2-[[8-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-2,11,20,29,37,39-hexaza-38,40-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1,3,5,7,9,11,13,15,17,19(39),20,22,24,26,28,30(37),31,33,35-nonadecaen-5-yl]oxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]-N-[2-[2-[2-[[2-[4-[2-[2-[2-[[8-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-2,11,20,29,37,39-hexaza-38,40-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1,3,5,7,9,11,13,15,17,19(39),20,22,24,26,28,30(37),31,33,35-nonadecaen-5-yl]oxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]acetyl]amino]ethoxy]propan-2-yloxy]ethyl]acetamide | 1394158-28-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: dizinc;2-[4-[2-[2-[2-[[8-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-2,11,20,29,37,39-hexaza-38,40-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1,3,5,7,9,11,13,15,17,19(39),20,22,24,26,28,30(37),31,33,35-nonadecaen-5-yl]oxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]-N-[2-[2-[2-[[2-[4-[2-[2-[2-[[8-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-2,11,20,29,37,39-hexaza-38,40-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1,3,5,7,9,11,13,15,17,19(39),20,22,24,26,28,30(37),31,33,35-nonadecaen-5-yl]oxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]acetyl]amino]ethoxy]propan-2-yloxy]ethyl]acetamide
• CAS: 1394158-28-1
• 化学式: C₁₀₇H₁₀₈N₂₄O₂₀Zn₂
• 分子量: 2180.96
• InChiKey: ZXGKUSWSQHOUKP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  10.82
• 重原子数：
  153
• 可旋转键数：
  56
• 环数：
  20.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  444
• 氢给体数：
  2
• 氢受体数：
  40

反应信息

• 作为产物：
  描述：

  ZINC;2-[4-[2-[2-[2-[[8-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-2,11,20,29,38,40-hexaza-37,39-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1(36),2,4,6,8,10(40),11,13,15,17,19,21(38),22,24,26,28,30,32,34-nonadecaen-5-yl]oxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]acetic acid 、 2,2-双（氨基乙氧基）丙烷 在 1-羟基苯并三唑 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 30.0h， 以42%的产率得到dizinc;2-[4-[2-[2-[2-[[8-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-2,11,20,29,37,39-hexaza-38,40-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1,3,5,7,9,11,13,15,17,19(39),20,22,24,26,28,30(37),31,33,35-nonadecaen-5-yl]oxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]-N-[2-[2-[2-[[2-[4-[2-[2-[2-[[8-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-2,11,20,29,37,39-hexaza-38,40-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1,3,5,7,9,11,13,15,17,19(39),20,22,24,26,28,30(37),31,33,35-nonadecaen-5-yl]oxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]acetyl]amino]ethoxy]propan-2-yloxy]ethyl]acetamide
  参考文献：
  名称：

  pH响应荧光探针和光敏剂基于自淬酞菁二聚体。

  摘要：

  制备了与酸敏感的缩酮单元连接的自淬灭的酞菁锌（II）酞菁二聚体，由于该缩酮连接体的裂解和三聚体的分离，可以在酸性环境中（pH = 5.0-6.5）进行活化。酞菁单元，从而导致增强的荧光发射和单线态氧的产生。

  DOI：

  10.1039/c2cc34327d

文献信息

• A pH-responsive fluorescent probe and photosensitiser based on a self-quenched phthalocyanine dimer
  作者：Mei-Rong Ke、Dennis K. P. Ng、Pui-Chi Lo

  DOI：10.1039/c2cc34327d

  日期：——

  A self-quenched zinc(II) phthalocyanine dimer linked with an acid-sensitive ketal unit has been prepared, which can be activated in an acidic environment (pH = 5.0-6.5) as a result of the cleavage of the ketal linker and separation of the phthalocyanine units, resulting in enhanced fluorescence emission and singlet oxygen production.

  制备了与酸敏感的缩酮单元连接的自淬灭的酞菁锌（II）酞菁二聚体，由于该缩酮连接体的裂解和三聚体的分离，可以在酸性环境中（pH = 5.0-6.5）进行活化。酞菁单元，从而导致增强的荧光发射和单线态氧的产生。