(4-chlorophenyl)(2-(hex-1-ynyl)phenyl)methanol | 1393803-63-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-chlorophenyl)(2-(hex-1-ynyl)phenyl)methanol
• 英文别名: (4-Chlorophenyl)-(2-hex-1-ynylphenyl)methanol
• CAS: 1393803-63-8
• 化学式: C₁₉H₁₉ClO
• 分子量: 298.812
• InChiKey: ZPHBBYJKVPLLLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (4-chlorophenyl)(2-(hex-1-ynyl)phenyl)methanol 在 水 、 碘 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以79%的产率得到2-butyl-3-(4-chlorophenyl)-1H-inden-1-one
  参考文献：
  名称：

  Molecular iodine mediated cyclization reactions of 2-(1-alkynyl)benzylic alcohols to substituted indenones

  摘要：

  efficient I-2-mediated approach to the synthesis of disubstituted indenones from readily available 2-alkynylbenzyl alcohols in the presence of H2O has been developed. These results are different from the known iodocyclization reactions in which O-containing heterocycles are obtained. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.06.030

文献信息

• Molecular iodine mediated cyclization reactions of 2-(1-alkynyl)benzylic alcohols to substituted indenones
  作者：Chengyu Wang、Jingyu Yang、Xingcan Cheng、Ende Li、Yanzhong Li

  DOI：10.1016/j.tetlet.2012.06.030

  日期：2012.8

  efficient I-2-mediated approach to the synthesis of disubstituted indenones from readily available 2-alkynylbenzyl alcohols in the presence of H2O has been developed. These results are different from the known iodocyclization reactions in which O-containing heterocycles are obtained. (c) 2012 Elsevier Ltd. All rights reserved.