N-(5'-oxo-2'-propylspiro[1,3-dihydroindene-2,4'-1H-imidazole]-5-yl)-2-(2-oxo-3-pyridin-2-ylbenzimidazol-1-yl)acetamide | 1219006-53-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: N-(5'-oxo-2'-propylspiro[1,3-dihydroindene-2,4'-1H-imidazole]-5-yl)-2-(2-oxo-3-pyridin-2-ylbenzimidazol-1-yl)acetamide
• CAS: 1219006-53-7
• 化学式: C₂₈H₂₆N₆O₃
• 分子量: 494.553
• InChiKey: NOFGLCLJOHMZSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] BICYCLIC DIHYDROIMIDAZOLONE CGRP RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DES RÉCEPTEURS DU CGRP À BASE DE DIHYDROIMIDAZOLONE BICYCLIQUE
  申请人：MERCK SHARP & DOHME

  公开号：WO2010033421A1

  公开（公告）日：2010-03-25

  Compounds of formula (I): wherein variables B, G1, G2, G3, G4, Ea, Eb, Ec, A1, A2, A3, A4, R6 and RPG and Y are as described herein, which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  公式（I）化合物：其中变量B、G1、G2、G3、G4、Ea、Eb、Ec、A1、A2、A3、A4、R6和RPG以及Y如本文所述，它们是CGRP受体拮抗剂，可用于治疗或预防CGRP参与的疾病，如偏头痛。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗CGRP参与的疾病中的用途。
• BICYCLIC DIHYDROIMIDAZOLONE CGRP RECEPTOR ANTAGONISTS
  申请人：Stump Craig A.

  公开号：US20110224230A1

  公开（公告）日：2011-09-15

  Compounds of formula (I): wherein variables B, G 1 , G 2 , G 3 , G 4 , E a , E b , E c , A 1 , A 2 , A 3 , A 4 , R 6 and R PG and Y are as described herein, which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  式(I)的化合物：其中变量B、G1、G2、G3、G4、Ea、Eb、Ec、A1、A2、A3、A4、R6和RPG以及Y如本文所述，它们是CGRP受体拮抗剂，并且在治疗或预防CGRP参与的疾病，如偏头痛方面有用。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗CGRP参与的这些疾病方面的使用。
• US8569291B2
  申请人：——

  公开号：US8569291B2

  公开（公告）日：2013-10-29