Ethyl {2,2-dichloro-1-[(phenylcarbonyl)amino]ethenyl}piperidin-1-ylphosphinate | 1334181-04-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl {2,2-dichloro-1-[(phenylcarbonyl)amino]ethenyl}piperidin-1-ylphosphinate
• 英文别名: N-[2,2-dichloro-1-[ethoxy(piperidin-1-yl)phosphoryl]ethenyl]benzamide
• CAS: 1334181-04-2
• 化学式: C₁₆H₂₁Cl₂N₂O₃P
• 分子量: 391.234
• InChiKey: XYSAOWOUNIIYAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ethyl {2,2-dichloro-1-[(phenylcarbonyl)amino]ethenyl}piperidin-1-ylphosphinate 以 甲醇 为溶剂， 生成 4-[Ethoxy(piperidin-1-yl)phosphoryl]-2-phenyl-5-piperidin-1-yl-1,3-oxazole
  参考文献：
  名称：

  Synthesis of new 4-phosphorylated derivatives of 5-amino-1,3-oxazole

  摘要：

  The N-1,1,1,2-Tetrachloroethylamides were found to react with diethyl amidophosphites via the Arbuzov reaction to afford N-substituted amides of ethyl 1-acylamino-2,2,2-trichloroethylphosphonic acids. A convenient method for the synthesis of new 4-phosphorylated 5-amino-1,3-oxazoles on their basis was developed.

  DOI：

  10.1134/s1070363211070115
• 作为产物：
  描述：

  piperidin-1-yl-phosphonous acid diethyl ester 在 三乙胺 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 120.0h， 生成 Ethyl {2,2-dichloro-1-[(phenylcarbonyl)amino]ethenyl}piperidin-1-ylphosphinate
  参考文献：
  名称：

  Synthesis of new 4-phosphorylated derivatives of 5-amino-1,3-oxazole

  摘要：

  The N-1,1,1,2-Tetrachloroethylamides were found to react with diethyl amidophosphites via the Arbuzov reaction to afford N-substituted amides of ethyl 1-acylamino-2,2,2-trichloroethylphosphonic acids. A convenient method for the synthesis of new 4-phosphorylated 5-amino-1,3-oxazoles on their basis was developed.

  DOI：

  10.1134/s1070363211070115

文献信息

• Synthesis of new 4-phosphorylated derivatives of 5-amino-1,3-oxazole
  作者：K. M. Kondratyuk、A. V. Golovchenko、T. V. Osadchuk、V. S. Brovarets

  DOI：10.1134/s1070363211070115

  日期：2011.7

  The N-1,1,1,2-Tetrachloroethylamides were found to react with diethyl amidophosphites via the Arbuzov reaction to afford N-substituted amides of ethyl 1-acylamino-2,2,2-trichloroethylphosphonic acids. A convenient method for the synthesis of new 4-phosphorylated 5-amino-1,3-oxazoles on their basis was developed.