1-(isoindolin-2-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxylic acid | 1188529-58-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 1-(isoindolin-2-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxylic acid
• 英文别名: 1-(1,3-Dihydroisoindol-2-ylsulfonyl)-2,3-dihydropyrido[2,3-b][1,4]oxazine-7-carboxylic acid
• CAS: 1188529-58-9
• 化学式: C₁₆H₁₅N₃O₅S
• 分子量: 361.378
• InChiKey: PKNJROBTEYKQPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• SUBSTITUTED PYRIDOXAZINES
  申请人：Newcom Jason S.

  公开号：US20090247502A1

  公开（公告）日：2009-10-01

  The invention provides compounds having the structure of formula I, and prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof, wherein A, Y and the groups R 1 , R 2 , R 3 and R 4 are defined in the specification. These compounds can be administered in pharmaceutical formulations to modulate cannabinoid receptor activity for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.

  该发明提供具有式I结构的化合物，以及它们的前药、立体异构体、混合物、盐、水合物、溶剂合物、酸盐水合物和同质晶形，其中A、Y以及基团R1、R2、R3和R4在说明书中有定义。这些化合物可以以药物配方形式给予，用于调节大麻素受体活性，预防和治疗各种疾病和症状，包括疼痛、炎症和瘙痒。
• US7960377B2
  申请人：——

  公开号：US7960377B2

  公开（公告）日：2011-06-14
• [EN] SUBSTITUTED PYRIDOXAZINES<br/>[FR] PYRIDOXAZINES SUBSTITUÉES
  申请人：CARA THERAPEUTICS INC

  公开号：WO2009120660A2

  公开（公告）日：2009-10-01

  The invention provides compounds having the structure of formula I, and prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof, wherein A, Y and the groups R1, R2, R3 and R4 are defined in the specification. These compounds can be administered in pharmaceutical formulations to modulate cannabinoid receptor activity for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.