acetic acid-(6β-chloro-cholesten-(4)-yl-(3β)-ester) | 6215-28-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: acetic acid-(6β-chloro-cholesten-(4)-yl-(3β)-ester)
• 英文别名: (10R)-6c-Chlor-3c-acetoxy-10r.13c-dimethyl-17c-((R)-1.5-dimethyl-hexyl)-(8cH.9tH.14tH)-Δ⁴-tetradecahydro-1H-cyclopenta[a]phenanthren；Essigsaeure-(6β-chlor-cholesten-(4)-yl-(3β)-ester)；6β-Chlor-3β-acetoxy-cholesten-(4)
• CAS: 6215-28-7
• 化学式: C₂₉H₄₇ClO₂
• 分子量: 463.144
• InChiKey: QGCKIQGDGXDSMJ-JBLNVDBQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.18
• 重原子数：
  32.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  acetic acid-(6β-chloro-cholesten-(4)-yl-(3β)-ester) 在 1,4-二氧六环 、 溶剂黄146 作用下， 生成 Cholest-5-en-3β,4β-diol-3-acetat
  参考文献：
  名称：

  Polyglucosan body disease in a mixed-breed dog

  摘要：

  AIM: To describe the histopathology of a previously unrecorded canine disease and deduce the cause of the lesions.METHODS: Formalin-fixed tissues were processed into paraffin wax and epoxy resin for light and electron microscopy of variously stained sections of liver, brain, heart muscle and kidney.RESULTS: Periodic acid Schiff (PAS)-positive bodies in liver and myocardium were typical of a polyglucosan body disease. Neurons contained coarse granular material that stained similarly to the polyglucosan bodies.CONCLUSION: The nature, distribution and histochemistry of lesions observed are consistent with a putative diagnosis of Glycogen storage disease type IV, an inherited metabolic defect associated with a deficiency of glycogen-branching enzyme not previously reported in dogs.

  DOI：

  10.1080/00480169.2002.36247
• 作为产物：
  描述：

  5α,6β-dibromocholestan-3β-ol 在 1,4-二氧六环 、 吡啶 、 氯化亚砜 、 乙醚 作用下， 生成 acetic acid-(6β-chloro-cholesten-(4)-yl-(3β)-ester)
  参考文献：
  名称：

  Polyglucosan body disease in a mixed-breed dog

  摘要：

  AIM: To describe the histopathology of a previously unrecorded canine disease and deduce the cause of the lesions.METHODS: Formalin-fixed tissues were processed into paraffin wax and epoxy resin for light and electron microscopy of variously stained sections of liver, brain, heart muscle and kidney.RESULTS: Periodic acid Schiff (PAS)-positive bodies in liver and myocardium were typical of a polyglucosan body disease. Neurons contained coarse granular material that stained similarly to the polyglucosan bodies.CONCLUSION: The nature, distribution and histochemistry of lesions observed are consistent with a putative diagnosis of Glycogen storage disease type IV, an inherited metabolic defect associated with a deficiency of glycogen-branching enzyme not previously reported in dogs.

  DOI：

  10.1080/00480169.2002.36247

文献信息

• Allylic Rearrangements. XLV.¹ The Reaction of Thionyl Chloride with 4β-Hydroxycholesteryl Benzoate
  作者：Robert E. Ireland、T. I. Wrigley、W. G. Young

  DOI：10.1021/ja01520a050

  日期：1959.6