(R,S)-2-benzyloxy-1,1-dimethoxypropane | 145866-78-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R,S)-2-benzyloxy-1,1-dimethoxypropane
• 英文别名: 1,1-Dimethoxypropan-2-yloxymethylbenzene
• CAS: 145866-78-0
• 化学式: C₁₂H₁₈O₃
• 分子量: 210.273
• InChiKey: OOZXUVRCXFMHPR-UHFFFAOYSA-N

物化性质

• 沸点：
  265.5±25.0 °C(Predicted)
• 密度：
  1.010±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R,S)-2-benzyloxy-1,1-dimethoxypropane 在 硫酸 作用下， 反应 1.0h， 以84%的产率得到2-苯基甲氧基丙醛
  参考文献：
  名称：

  Fetter, Jozsef; Bertha, Ferenc; Kajtar-Peredy, Maria, Journal of Chemical Research, Miniprint, 1997, # 4, p. 725 - 748

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1-二甲氧基丙酮 在 甲醇 、 sodium tetrahydroborate 、 sodium 作用下， 以 甲醇 为溶剂， 反应 2.25h， 生成 (R,S)-2-benzyloxy-1,1-dimethoxypropane
  参考文献：
  名称：

  Fetter, Jozsef; Bertha, Ferenc; Kajtar-Peredy, Maria, Journal of Chemical Research, Miniprint, 1997, # 4, p. 725 - 748

  摘要：

  DOI：

文献信息

• Modulators of proteolysis and associated methods of use
  申请人：Arvinas Operations, Inc.

  公开号：US11161841B2

  公开（公告）日：2021-11-02

  The present disclosure relates to bifunctional compounds, which find utility as modulators of Kirsten rat sarcoma protein (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation, accumulation, and/or overactivation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，它们可用作 Kirsten 大鼠肉瘤蛋白（靶蛋白）的调节剂。特别是，本公开涉及双功能化合物，其一端含有与相应 E3 泛素连接酶结合的 Von Hippel-Lindau、cereblon、Apotosis Proteins 抑制剂或小鼠双敏同源物 2 配体，另一端含有与靶蛋白结合的分子，从而使靶蛋白靠近泛素连接酶以实现对靶蛋白的降解（和抑制）。本公开物具有与降解/抑制靶蛋白相关的广泛药理活性。本公开的化合物和组合物可以治疗或预防因目标蛋白的聚集、积累和/或过度激活而导致的疾病或失调。
• Anti-selective reaction of .alpha.-sulfenyl acetals with silylated carbon nucleophiles. Scope, limitation, and mechanism
  作者：Kazuaki Kudo、Yukihiko Hashimoto、Makoto Sukegawa、Masaki Hasegawa、Kazuhiko Saigo

  DOI：10.1021/jo00055a009

  日期：1993.1

  In the presence of a Lewis acid, alpha-sulfenyl acetals 1 reacted with various silylated carbon nucleophiles 2 to give anti adducts (anti-3) with high diastereoselectivity. The stereochemistry was only slightly affected by the reaction conditions, such as temperature, solvent, and Lewis acid. However, the structure of substrate 1 and the kind of nucleophile 2 had considerable effect on the stereochemical course of the reaction. Almost exclusive anti selectivity was attained when 1,1-dimethoxy-2-(tert-butylthio)propane (1b) was used as a substrate or when ketene silyl acetal 2c was employed as a nucleophile. The mechanism of this reaction is essentially S(N)2, although the S(N)1 process participates to a various extent, depending on the structure of substrate 1. The usefulness of this anti-selective reaction was exemplified by the easy transformation of anti-3o to synthetically valuable allylic alcohol anti-6 without any loss of stereochemical information. The reaction of alpha-(benzyloxy)acetal 4 with 2 was also investigated. It gave a syn-rich mixture of diastereomers with lower selectivity.
• MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE
  申请人：Arvinas Operations, Inc.

  公开号：EP3774777A2

  公开（公告）日：2021-02-17
• [EN] DERIVATIVES OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5- AMINE<br/>[FR] DÉRIVÉS DE 6- (2,3-DICHLOROPHÉNYL) -1,2,4-TRIAZIN -5-AMINE
  申请人：NEKTAR THERAPEUTICS INDIA PVT LTD

  公开号：WO2015092819A2

  公开（公告）日：2015-06-25

  The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided possess unique effects and differences over other phenyltriazines known in the art.